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SİGARANIN HEMODİYALİZ HASTALARINDA OKSİDATİF STRES ÜZERİNE ETKİSİ

THE EFFECTS OF SMOKING ON OXIDATIVE STRESS IN HEMODIALYSIS PATIENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Oxidative stress has been shown in either hemodialysis patients or smokers in relation with an increased production of free radicals. We want to assess the effects of smoking on oxidative stress markers; malondialdehyde (MDA), protein carbonyl content and total sulfhydryl groups, in chronic hemodialysis (HD) patients. Ten smoker HD patients (6 men and 4 women, ages 44 ± 14 years), ten non-smoker HD patients (6 men and 4 women, ages 55 ± II years) and ten non-smoker healty subjects as a control were recruited. The results showed that serum MDA and protein carbonyl levels were found to be significantly increased either in smoker HD patients (p<0.05, p<0.05) or in non-smoker HD patients (p<0.05, p<0,05). Also there was a significant difference in serum MDA and carbonyl content levels between smoker and non-smoker HD patients (p<0.05). Serum total sulfhydryl groups in smoker and non-smoker patients were significantly lower than those in controls. (p<0.05, p<0,05). Conclusion; We demonstrate smoking may aggrevate oxidative stress in hemodialysis patient.
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Abstract (Original Language): 
Hem hemodiyaliz hastalarında hem de sigara içenlerde serbest radikal oluşumu ile oksidatif stresin arttığı gösterilmiştir. Biz bu çalışmamızda kronik hemodiyaliz (HD) hastalarında sigaranın oksidatif stres markerları olan malondialdehid (MDA), protein karbonil içeriği ve total sülfıdril grupları üzerine etkisini araştırdık. Çalışmaya 10 sigara içen HD hastası (6 erkek,4 kadın yaş:44 ± 14), 10 sigara içmeyen HD hastası (6 erkek, 4 kadın yaş: 55 ± 11) ve kontrol olarak 10 sigara içmeyen sağlıklı kişi alındı. Çalışmanın sonucunda serum MDA ve protein karbonil içeriği hem sigara içen (p<0,05, p<0,05) hem de içmeyen (p<0,05, p<0,05) HD hastalarında kontrolden anlamlı olarak yüksek bulundu. MDA ve protein karbonil içeriği sigara içen HD hastalarında içmeyenlerden anlamlı olarak yüksekti (p<0.05, p<0,05). Total sülfıdril grupları düzeyi ise her iki grupta da kontrolden anlamlı olarak düşüktü (p<0,05, p<0,05). Sonuç olarak sigara, hemodiyaliz hastalarında oksidatif stresin daha da artmasına yol açmıştır.
FULL TEXT (PDF): 
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  • 2
121-124
  • Turkish

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