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HİPERTİROİDİ HASTALARINDA PLAZMA OKSİDATİF PROTEİN HASARI

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Plasma oxıdatıve protein damage in hyperthyroid patıents. Various cellular processes in which proteins take part arc affected by oxidative modİfications. Oxidativc stress has been re-ported to be inercased in hyperıhyroidism. We determined plasma oxidative protein damage parameters by coiorimetıic methods in 20 hyperthyroid patients and in 20 euthyroid controls in order to investigate oxidative protein damage in plasma proteins in hypcrthyroidism. Plasma protein carbonyl levels of hyperthyroid paüents wcre significantly inereased comparcd to the controls. On the other hand, plasma protein thiol, total thiol, nonprotein thİol, unsaturated İron binding capacity ievels of hyperthyroid patients were not significantly dİfferent from tho-se of the controls. In hyperthyroid patients, plasma lipid hydroperoxide levels were significantly inereased, and erythrocyte glutaîhionc levels were significantly decreased compared to the control group. In coııchısion, we found that plasma oxidative protein damage was inereased in hyperthyroid paiient.s.
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Abstract (Original Language): 
Proteinlerin rol oynadığı çeşitli hücresel olaylar proteinlerin oksidatif modifikasyonundan etkilenir. Hİpcıtiroidizmde oksidatif stresin arttığı bildirilmektedir. Hipcrtiroidi hastalarında olası oksidatif protein hasarını plazma proteinlerinde araştırmak amacı ife, 20 hipcrtiroidi hastası ve 20 ötiroid kontrolde kolorimetrik yöntemlerle plazma oksidatif protein hasar parametrelerini inceledik. Hipertİroidi hastalarının plazma protein karbonil düzeyleri kontrol grubuna göre anlamlı derecede yüksekti. Diğer taraftan, hipertiroidi hastaları ile kontrol grubu arasında protein tiol, total tiol, nonproteİn tiol, doymamiş demir bağlama kapasitesi düzeyleri bakımından istatistiksel olarak anlamlı bir fark saptanmadı. Hipertiroidİ hastalarının plazma Sipid hidrope-roksid düzeyleri kontrol grubuna göre anlamlı derecede yüksek, eritrosit glutatyon düzeyleri ise anlamlı derecede düşüktü. Sonuç olarak, bipertİroidi hastalarında plazma oksidatif protein hasarının artmış olduğunu saptadık
FULL TEXT (PDF): 
PDF icon arastirmax-hipertiroidi-hastalarinda-plazma-oksidatif-protein-hasari.pdf
  • 4
411-414
  • Turkish

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