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YAŞLANMANIN PLAZMA OKSİDATİF PROTEİN HASARINA ETKİSİ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
An increase in oxidative stress may contribute to the development of oxidative protein damage in aging. In the present study, we investigated the relation between aging and oxidative protein damage parameters such as plasma protein carbonyl and protein thiol, as well as oxidative stress parameters such as total thiol, nonprotein thiol and lipid hydroperoxides in the plasma samples of young adult, adult and young old individuals. Results.- Protein carbonyl and lipid hydroperoxide levels were significantly increased in aging individuals. On the other hand, total thiol and protein thiol levels were significantly decreased in aging individuals. Protein carbonyl, protein thiol, and lipid hydroperoxide levels were significantly correlated with age. Conclusion.- The result of this study suggests that increased plasma protein carbonyl levels and decreased plasma protein thiol levels in aging individuals may reflect the oxidative protein damage.
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Abstract (Original Language): 
Oksidatif streste artış yaşlanma ile gelişen oksidatif protein hasarının sebeplerinden biri olabilir. Bu çalışmada, yaşlanma ile oksidatif protein hasar ı parametrelerinden plazma protein karbonil ve protein tiolün yanı sıra, total tiol, nonprotein tiol ve lipid hidroperoksidleri gibi oksidatif stres parametreleri arasındaki ilişkiyi genç erişkin, erişkin ve genç yaşlı bireylerin plazmalarõnda araştırdık. Genç yaşlı grupta protein karbonil ve lipid hidroperoksid düzeyleri genç erişkin ve erişkin gruplara göre anlamlı olarak artmıştı. Yaş ile protein karbonil ve lipid hidroperoksid düzeyleri aras ında anlamlı bir korelasyon bulunmas ına karşılık, protein karbonil düzeyleri ile lipid hidroperoksid düzeyleri aras ında korelasyon mevcut değildi. Genç yaşlı grupta total tiol ve protein tiol düzeyleri genç erişkin ve erişkin gruplara göre anlamlı olarak azalmıştı. Bu çalışmanın sonuçları yaşlanma ile artan plazma protein karbonil düzeyleri ile azalan plazma tiol düzeylerinin oksidatif protein hasarındaki artışın göstergesi olabileceğini ortaya koymaktad ır.
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  • 4
220-223
  • Turkish

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