Buradasınız

Anasayfa » Content

FORMULATION AND EVALUTION OF FAST DISPERSIBLE TABLET OF FEXOFENADINE HCl

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The purpose of this research was to formulate tasteless complexes of Fexofenadine Hydrochloride with Kyron-134 and to formulate tasteless complex into fast-Dispersible tablets (FDT) for the treatment of allergic rhinitis & chronic idiopathic urticaria. Tasteless Drug resin complexes (DRC) were prepared using combination of Kyron-134 & drug in different ratio(1:3) and evaluated for different factor affecting Drug-Resin Complexation, Complexation time, stirring time, soaking time, temperature, and effect of pH on Fexofenadine Hydrochloride loading on Kyron-134. Fexofenadine Hydrochloride release from FDT is obtained at salivary and gastric pH. Infrared spectroscopy & DSC revealed Complexation of -NH (drug) with Kyron-134. Drug release from FDT in salivary pH was insufficient to impart bitter taste. Complete drug release was observed at gastric pH. The values of pre-compression parameters evaluated, were within prescribed limits and indicated good free flowing properties. The tablets were evaluated for post-compression parameters such as weight variation, hardness, and friability, wetting time, content uniformity, disintegration time and dissolution. The study conclusively demonstrated significant taste masking of API and rapidly dispersible and dissolution. Maximum loading was obtained at drug-resin ratio 1:3, pH 6-7, temperature 60 °C, soaking time 60 min and stirring time 5-6 hr. Formulation D-5 containing Kyron-314 (66.66%) & CSS (33.33%) show optimum result among all formulation. The studies indicate that the formulation was taste masked drug can be formulated in to FDT with view to enhance patient compliance & to obtain faster onset action of the drug which would be advantageous in comparison to the currently available conventional forms. Formulations D-5 was found to be palatable with in vitro disintegration time of 20 s Dissolution studies showed complete release of D-5 within 30 min.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-formulation-and-evalution-fast-dispersible-tablet-fexofenadine-hcl.pdf
  • 3
  • English

REFERENCES

References: 

1.
Chei
n YW: Oral Drug Delivery and Delivery Systems. 2nd Ed. New York: Marcel Dekker; 1992.
2.
Kau
r T, Bhawandeep G, Sandeep K and Gupta GD: Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res. 2011; 3: 1-7.
3. Augsburger LL and Stephen WH: Orally disintegrating tablets pharmaceutical dosage forms: tablets. Infroma Healthcare
Publication, 3rd Ed. 2; 293-312.
4. Nanda A, Kandarapu R and GARG S: An
update on taste masking technologies for oral pharmaceuticals. Ind. J. Pharm. Sci. 2002; 64: 10-17.
5.
Fexofenadin
e HCl, November 2011, www.wikipedia.org/Fexofenadine
6.
Pate
l TN, Patel RP and Patel BV, Taste Masking of Topiramate by Newer Range of Ion-Exchange Resin. International Journal of Pharmaceutical Sciences and
Nanotechnology. 2010; 3: 1105-10.
7. Devi NK, Rani AP, Madhavi BR: Studies
on taste masking of levocetrizine di hydrochloride using ion - exchange resins. Research Journal of Pharmaceutical,
Biological and Chemical Sciences. 2010; 1: 245-253.
8. Mundad A, Meshram D, Banbale H, Bhalekar M and Avari J: Formulation and evaluation of dispersible taste masked tablet of Roxithromycin. Asian Journal of Pharmaceutics, 2008, 116-119.
9. Puttewar TY, Kshirsagar MD, Chandewar AV and Chikhale RV: Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin. Journal of King Saud University (Science). 2010; 22: 229-240.
10. Wani SU, Shamkuwar P and Nagnath A: Formulation of Drug-Resin complex and evaluation of its molecular property & release kinetics. Scholars Research Library.
Der Pharmacia Lettre. 2010; 2(5): 155-164.
11. Lachman L, Lieberman HA and Kanig JL: The Theory and Practice of Industrial Pharmacy, 4th Ed, Varghese publishing house, Mumbai 1987: 171-293.
12. Wells JI and Aulton ME, Pharmaceutics the science of dosage form design; 2nd Ed, Churchill Livingstone. 2002: 223-253.
13.
India
n Pharmacopoeia, the Indian pharmacopoeia commission, Ghaziabad, volume-I, 2010: 187-193.
14.
Simone S
and Peter CS: Fast dispersible ibuprofen tablets. European Journal of Pharmaceutical Sciences. 2002; 15: 295¬305.

Thank you for copying data from http://www.arastirmax.com