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FORMULATION DEVELOPMENT AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF OXCARBAZEPINE

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2015

Key Words:

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Abstract (2. Language): 
The objective of this study was formulation, development and evaluation of Oxcarbazepine Fast Dissolving Tablets (FDTs) prepared by using novel co-processed super-disintegrants. FDTs were prepared by direct compression method using co-processed super-disintegrants crosscarmellose sodium and sodium starch glycolate in different ratios (1:1, 1:2, and 1:3). The prepared FDTs were evaluated for weight variation, thickness, drug content, friability, hardness, wetting time, water absorption ratio, in-vitro dispersion time, invitro disintegration time and invitro dissolution time. The optimized batch (F9) was subjected to stability testing for 3 months at temperatures 400C and 75% relative humidity and at room temperature and at 60% relative humidity. All the prepared formulae complied with Pharmacopoeial requirements of drug contents. FDT formula F9 has shown no appreciable changes with respect to physical characters, Drug content, in vitro dispersion and dissolution profiles when stored at prescribed temperature and relative humidity.
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