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DİŞ HEKİMLİĞİNDE DOKU MÜHENDİSLİĞİNİN YERİ

Tissue Engineering in Dentistry

Journal Name:

Publication Year:

Abstract (2. Language): 
Tissue engineering is a field of a engineering that aims to restore damaged tissues and organs. It is based on to integrate cells on a specific natural or synthetic scaffolds with the specific signals. In this brief review dental tissue engineering has been examined under two headings; (i) strategies and (ii) applications. In the strategies tissue conduction, tissue induction, stem cell transplantation and gene therapy have been described. The various tissues of the oral cavity such as bone, cartilage, dentin, dental pulp, and salivary gland engineering have been reviewed as applications. Skin and cartilage tissues after processing in the laboratory with tissue engineering strategies, have been used in some medical applications. Although the wide variety of tissue engineering applications in various tissues of the oral cavity made revolution in dentistry, more research on the treatment of complex tissue defects are needed
Abstract (Original Language): 
Doku mühendisliği hasarlı doku ve organların yeniden restore edilmesini amaçlayan bir mühendislik dalıdır. Bu mühendislik dalı, hücrelerin doğal veya sentetik yapı iskelelerine spesifik sinyallerle entegre edilmesi üzerine kurulmuştur. Bu kısa derlemede diş hekimliğinde doku mühedisliği stratejiler ve uygulama alanları olarak iki başlık altında incelenmiştir. Doku mühendisliği stratejilerinde doku kondüksiyonu, doku indüksiyonu, kök hücre nakli ve gen terapisi tanımlanmış, doku mühendisliği uygulama alanlarında da oral kavitenin kemik, kıkırdak, dentin, dental pulpa ve tükürük bezi gibi çeşitli dokularında yapılan rejeneratif çalışmalar incelenmiştir. Doku mühendisliği stratejileri ile bugün, deri, kıkırdak gibi dokular laboratuvarda işlendikten sonra bazı medikal uygulamalarda kullanılabil¬mektedir. Oral kavitenin çeşitli dokularında çok geniş uygulama alanları bulunan doku mühendisliği, diş hekimliğinde devrim niteliğinde olsa da kompleks doku defektlerinin tedavisi üzerine daha çok araştırma yapılmasına ihtiyaç vardır.
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REFERENCES

References: 

1.
Tyag
i P. Dhindsa MK. Tissue engineering and its implications in dentistry. Indian J. Dent. Res, 2009; 20: 222-26.
2. Nerem
R
, Sambanis A. Tissue engineering from biology to biological substitu¬tes. Tissue Eng, 1995; 1: 3-13.
3.
Kaigle
r D, Mooney D. Tissue engineering's impact on dentistry. J Dent
Educ, 2001; 65: 456-62.
4.
Bau
m BJ, Mooney DJ The impact of tissue engineering on dentistry. J Am Dent Assoc, 2000; 131: 309-18.
5.
Ricc
i JL, Terracio L. Where is dentistry in regenerative medicine . Int Dent J, 2011; 61: 2-10.
6. Ikeda E, Tsuji T. Growing bioengi-neered teeth from single cells: potential for dental regeberative medicine. Expert Opin
Biol Ther, 2008: 8; 735-44.
7.
Schelle
r EL, Krebsbach PH, Kohn DH. Tissue engineering: state of the art in oral rehabilitation. J Oral Rehabil, 2009:
36; 368-89.
Z.
Selin SIRIK, S. ERGlN, F. Gülbahar IŞIK
8.
Damien CJ,
Parson
s JR. Bone graft and bone graft substitutes: a review of current technology and applications. J Appl Biomater, 1991: 2; 187-208.
9.
Goldber
g VM, Stevenson S. Natural history of autografts and allografts. Clin Orthop Relat Res, 1987; 225: 7-16.
10.
Blaes
e RM, Culver KW, Miller AD, Carter CS, Fleisher T, Clerici M, et al. T lymphocytes-directed gene theraphy for ADA-SCID:Initial trial results after 4 years. Science, 1995; 270: 475-80.
11.
Anderso
n WF. Human gene therapy. Nature, 1998; 392: 25-30.
12.
Nabel
GJ
. Development of optimized vectors for gene theraphy. Proc Natl Acad Sci USA, 1999; 96: 324-26
13.
Gleich
LL
, Gluckman JL, Armstrong S, Biddinger PW, Miller MA, Balakrishnan K, et al. Alloantigen gene theraphy for squ-amous cell carcinoma of the head and neck: Results of a phase- 1 trial. Arch Otolaryngol Head Neck Surg, 1998; 124: 1097-104.
14. Wollenberg B, Kastenbauer, Mundl H, Schaumberg J, Mayer A, Andratschke M, et al. Gene theraphy-phase 1 trial for primary untreated head and neck squamous cell cancer (HNSCC) UICC stage II-IV with a single interumoral injection of hIL-2 plasmids formulated in DOTMA/Chol. Hum Gene Ther, 1999; 10: 141-47.
15.
Mjyer
s JN. The use of biological the-raphy in cancer of the head and neck. Curr Prob Cancer, 1999; 23: 106-34.
16. Shea LD, et al: DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol, 1999; 17: 551-54.
17. Urist MR. Bone: formation by auto¬induction. Science, 1965; 150(3698): 893¬99.
18.
Cochra
n DL, Wozney JM. Biologi¬cal mediators for periodontal regeneration.
Periodontol 2000, 1999; 19: 40-58.
54
Diş Hekimliğinde Doku Mühendisliğinin Yeri
19. Akgün ÖM, Polat GG, Altun C. Re-jeneratif Pulpa Tedavilerinde Doku Mühendisliği Uygulamaları Ado Klinik Bilimleri
Dergisi, 2008; 2: 238-44.
20. Polverini PJ. The pathophsiology of angiogenesis. Crit Rev Biol Med, 1995; 6:
230-47.
21. Heijl L, et al:
Ename
l matrix derivative (emdogain) in the treatment of intrabony periodontal defects. J Clin Periodontol, 1997; 24: 705-14.
22. Tamura RN, et al: Coating of titani¬um alloy with soluble laminin-5 promotes cell attachment and hemidesmosome as¬sembly in gingival epithelial cells: potential application to dental implants. J Periodontol Res, 1997; 32: 287-94.
23.
Sherida
n ME, Shea LD, Peters MC, Mooney DJ. Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J Control
Release, 2000; 64: 91-102.
24.
Morriso
n G. Adances in the skin trade. Mech Engg, 1999; 121: 40-43.
25.
Mizun
o H, et al: Succesful culture and sustainability in vivo of gene-modified human oral mucosal epithelium . Hum Gene
Ther, 1999; 10: 825-30.
26.
Garli
c JA,Fenjves ES. Keratinocyte gene transfer and gene therapy. Crit Rev Oral
Bio Med, 1996; 7: 204-21.
27. Brittber M, et al: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med, 1994; 331: 889-95.
28.
Ca
o Y, et al: Transplantation of chondrocytes utilizing a polymer cell cons¬truct to produce tissue engineered cartilage in the shape of a human ear. Plast Reconstr Surg, 1997; 100: 297-304.
29.
Puelache
r WC, Money D, Palge KT, Upton J, Vacanti CA. Design of nasosep-tal cartilage replacements synthesized form
biodegradable polymers and chondrocytes. Biomaterials, 1994; 15: 774-78.
30.
Ji
n QM, et al: Cementum engineering with three-dimensional polymer scaffolds. J Biomed Mater Res A, 2003; 67: 54-60.
31.
Ki
m BS, Nikolovski J, Bonadio J, Smiley J, Mooney DJ. Engineered smooth muscle tissues. Regulating cell phenotype with the scaffold. Exp Cell Res, 1999; 251: 318-28.
32.
Vacant
i CA, Kim W, Upton J, Vacanti MP, Mooney D, Schloo B et al. Tissue engineered growth of bone and cartilage. Transplant Proc, 1993: 25; 1019-21.
33.
Ishaug-Rile
y SL, Crane GM, Gurlek A, Miller MJ, Yasko AW, Yaszemski MJ et al. Ectopic bone formation by marrow stromal osteoblast transplantation using poly(DL-lactic-co-glycolic acid) foams transplanted into the rat mesentery. J Biomed Mater Res, 1997; 36: 1-8.
34. Krebsbach PH,
Kuznetso
v SA, Sato-mura K, Emmons RV, Rowe DW, Robey PG. Bone formation in vivo:comparison of oste-ogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation, 1997: 63; 1059-69.
35.
Laurenci
n CT, El-Amin SF, Ibim SE, Willoughby DA, Attawia M, Allcock HR et al. A highly porous 3-dimensional polyphosphazene polymer matri for skeletal tissue regeneration. J. Biomed Mater Res, 1996; 30: 133-38.
36.
Gorn
a K, Gogolewski S. Preparation, degradation and calfication of biodegradable polyurethane foams for bone graft substitu-des. J Biomed Mater Res, 2003: 67; 813-27.
37.
L
i WJ, Tuli R Huang X, Laquerriere P, Tuan RS. Multilineage differentiation of human mesenchymal stem cells in a three-dimensional nanofibrous scaffold. Biomaterials, 2005; 26: 5158-66.
38.
Nuttelma
n CR, Trpodi MC, Anseth
55
Ks. In vitro osteogenic differentiation of human mesenchymal stem cells photoencap-sulated in PEG hydrogels. J Biomed Mater
Res, 2004: 68; 773-82.
39.
Payn
e RG, McGonigle JS, Yaszems-ki MJ, Yasko AW, Mikos AG. Development of an injectable, in situ crosslinkable, deg-radable polymeric carrier for osteogenic cell populations. Part 3. Proliferation and differentiation of encapsulated marrow stromal osteoblasts cultured on crosslinking poly(propylene fumarate). Biomaterials, 2002; 23: 4381-87.
40.
Marque
s AP, Cruz HR Coutinho OP, Reis RL. Effect of starch-based biomaterials on the in vitro proliferation and viability of osteoblast-like cells. J Mater Sci Mater Med, 2005; 16: 833-42.
41. Alsberg
E
, Anderson KW, Albei-ruti A, Franceschi RT, Mooney DJ. Cell-interactive alginate hydrogels for bone tissue engineering. J Dent Res, 2001; 80: 2025-29.
42. Xu
WP
, Zhang W, Asrican R, Kim HJ, Kaplan DL, Yelick PC. Accurately shaped tooth bud cell-derived mineralized tissue formation on silk scaffolds. Tissue Eng Part A, 2008; 14: 549- 57.
43.
Ducheyn
e P, el-GhannamA, Shapiro I. Effect of bioactive glass templates on os-teoblast proliferation and in vitro synthesis of bone-like tissue. J Cell Biochem, 1994; 56: 162-67.
44.
Reill
y GC, Radin S, Chen AT, Ducheyne P. Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal stem cells to 45S5 bioactive glass. Biomaterials, 2007; 28:
4091-97.
45.
Ohgush
i H, Okumura M, Tamai S, Shors EC, Caplan AI. Marrow cell indu¬ced osteogenesis in porous hydroxyapatite and tricalcium phosphate: a comparative histomorphometric study of ectopic bone
Z.
Selin SIRIK, S. ERGAN, F. Gülbahar IŞIK
formation. J Biomed Mater Res, 1990; 24: 1563-70.
46.
Yoshikaw
a T, Ohgushi H, Tamai S. Immediate bone forming capability of prefabricated osteogenic hydroxyapatite. J Biomed Mater Res, 1996; 32: 481-92.
47.
Thomso
n RC, Yaszemski MJ, Powers JM, Mikos AG. Hydroxyapatite fiber reinforced poly(alpha-hydroxy ester) foams for bone regeneration. Biomaterials, 1998; 19:1935-43.
48.
Kretlo
w JD, Mikos AG. Review: mi¬neralization of synthetic polymer scaffolds for bone tissue engineering. Tissue Eng,
2007; 13: 927-38.
49.
Segvic
h S, Smith HC, Luong LN, Kohn DH. Uniform deposition of protein incorporated mineral layer on threedimensio-nal porous polymer scaffolds. J Biomed Mater Res B Appl Biomater, 2008; 84: 340-49.
50.
Ciocc
a L, De Crescenzio F, Fantini M, Scotti R. CAD/CAM and rapid prototyped scaffold construction for bone regenerative medicine and surgical transfer of virtual planning: a pilot study. Comput Med Ima¬ging Graph 2009: 33; 58-62.
51.
Fortie
r LA. Stemcells: classification, controversies and clinical applications. Vet Surg, 2005; 34: 415-23.
52.
Wan
g Y, Preston B, Guan G. Tooth bioengineering leads the next generation of dentistry. Int J Paediatr Dent 2012 doi:10.1111/j.1365-263x.2011.01206x (inp¬ress)
53.
Ikad
a Y. Challenges in tissue engineering. Journal of the Royal Society Interface,
2006; 22: 589-601.
54.
Hen
g BC ve Cao T, Stanton lW, Rob-son P, Olsen B. Strategies for directing the differentiation of stem cells into the osteo-genic lineage in vitro. J Bone Miner Res,
2004; 19: 1379-94.
55.
Ye
n AH, Sharpe PT. Stem cells and
56
Diş Hekimliğinde Doku Mühendisliğinin Yeri
tooth tissue engineering. Cell Tissue Res, 2008; 331: 359-72.
56.
Grontho
s S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A et al. Stem cell properties of human dental pulp stem cells. J Dent Res, 2002; 81: 531-35.
57.
Se
o BM, Miura M, Gronthos S, Bar-told PM, Batouli S, Brahim J et al. Inves¬tigation of multipotent postnatal stem cells from human periodontal ligament. Lancet, 2004; 364: 149-55.
58.
Sauerbier
S,
Stricker
A
, Kuschnierz J, Bühler F, Oshima T, Xavier SP, Schmelzeisen R, Gutwald R. In vivo comparison of hard tissue regeneration with human me-senchymal stemcells processed with either the FICOLL method or the BMAC method. Tissue Eng Patr C Methods 2010: 16; 215¬23.
59.
Morsczec
k C, et al: Somatic stem cells for regenerative dentistry. Clin Oral Investig, 2008; 12: 113-18.
60.
Bluteau G,
Lude
r HU, De Bari C, Mitsiadis TA. Stem cells for tooth enginee¬ring. Eur Cell Mater, 2008; 16: 1-9.
61. Nakahara T. Potential feasibility of detal
ste
m cells fo regenerative therapies: stem cell transplantation and whole tooth engineering Odontology, 2011; 99: 105-11.
62.
Ya
o S, Pan F, Prpic V, Wise GE. Differentiation of stem cells in the dental
follicle. J Dent Res, 2008; 87: 767-71.
63.
Che
n F, et al: Anchoring dental implant in tissue engineered bone using com¬posite scaffold: a preliminary study in nude mouse model. J Oral and Maxillofac Surg,
2006; 63: 586-91.
64. Dunn CA, et al: BMP gene delivery for alveolar bone engineering at dental implant defects. Mol Ther, 2005; 11: 294-99.
65.
Hib
i H, Yamada Y, Kagami H, Ueda M. Distraction osteogenesis assisted by tis¬sue engineering in an irradiated mandible:
a case report. Int J Oral Maillofac Implants,
2006; 1: 141-47.
66.
It
o K, et al; Simultaneous implant placement and bone regeneration around dental implants using tissue- engineered bone with fibrin glue, mesenchymal stem cells and platelet-rich plasma. Clin Oral Implants
Res, 2006; 17: 579-86.
67. Yamada Y, et al: Tissue-engineered injectable bone regeneration for osseointeg-rated dental implants. Clin Oral Implants
Res, 2004; 15: 589-97.
68.
Yamad
a Y, Ueda M Hibi H, Naga-saka T. Translational research for injectable tissue engineered bone regeneration using mesenchymal stemcells and platelet-rich plasma from basic research to clinical case study . Cell Transplant, 2004: 13: 343-55.
69. Yamada Y, Ueda M, Naiki T, Taka-
hashi M, Hata K, Nagasaka T. Autogenous injectable bone for regeneration with me-senchymal stem cells and platelet rich plas¬ma: tissue engineered bone regeneration. Tissue engineered bone egeneration. Tissue
Eng, 2004: 10: 955-64.
70. Xu
HH
, Zhao L, Weir MD. Stem-cell-calcium phosphate constructs for bone engineering. J Dent Res, 2010; 89: 1482-88.
71.
Mare
i MK, et al: Preservation and regeneration of alveolar bone by tissue-en¬gineered implants. Tissue Eng, 2005; 11: 751-67.
72. Schmelzeisen
R
, et al: Making Bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation - a preliminary report. J Craniomaxillofac Surg, 2003; 31: 34-39.
73. Zizelmann
C
, Schoen R, Metzger MC, Schmelzeisen R, Schramm A, Dott B, Bormann KH, Gelrich NC. Bone formation after sinus augmentation with engineered
bone. Clin Oral Impl Res, 2007; 18: 69-73.
74.
Durain
e G, Hu J, Athanasoiu K. Bio-
57
engineering in the oral cavity: insights from articular cartilage tissue engineering. Int J Oral Maxillofac Implants. 2011; 26: 11-24.
75.
Ji
n X. Recent progress of researches in cartilage tissue engineering. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2011; 25: 187-92.
76. Murray PE, et al: Regenerative en-dodontics: a review of current status and a
call for action. J Endod, 2007; 33: 377-87.
77.
Hackin
g SA, Khademhosseini A. Applications of microscale technologies for regenerative dentistry. J Dent Res, 2009; 88:
409-21.
78.
Prescot
t RS, et al: In vivo generation of dental pulp-like tissue by using dental pulp stem cells, a collagen scaffold, and dentin matrix protein 1 after subcutaneous transplantation in mice. J Endod, 2008; 34:
421-26.
79. Yıldırım S, Alaçam A, Sarıtaş ZK, Oygür T. Transforming Growth Factor B1'in pulpa tedavilerinde kullanılabilirliğinin his-topatolojik olarak araştırılması. GÜ Diş Hek Fak Derg, 2001; 18: 123-32.
80.
Xi
e HT, Wang GJ, Sun JG, Tucker I, Zhao XC, Xie YY et al. High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies. J Chromatogr, 2005; 818: 167-73.
81.
Kagam
i H, Wang S, Hai B. Restoring the function of salivary glands. Oral Dis, 2008; 14: 15-24.
82.
Sugit
o T, Kagami H, Hata H. Transplantation of cultured salivary gland cells into an atrophic saivary gland. Cell Trans¬plant, 2004; 13: 691-99.
83.
Delport
e C, O'Connell BC, He X. Increased fluid secretaion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl
Z.
Selin SIRIK, S. ERGlN, F. Gülbahar IŞIK
Acad Sci U
S A 1997; 94: 3268-73.
84. Pena
I
, Junquera LM. Meana A, Garcia E, Aguilar C, Fresno FM. In vivo behavior of complete human oral mucosa equivalents: characterization in athymic mice. J Periodont Res, 2011; 46: 214-20.
85. Ueda M, Tohnai I, Nakai H. Tissue engineering research in oral implant surgery. Artif Organs, 2001; 25: 164-71.
86.
Garcia-Godo
y F, Murray P. Regenerative Dentistry: Translating Advancements in Basic Science Research to the Dental Practice. J Tenn Dent Assoc, 2010; 90: 12-8.

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