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An Evaluation & Correlation of C-Reactive Protein & Malondialdehyde in Acute Myocardial Infarction

An Evaluation & Correlation of C-Reactive Protein & Malondialdehyde in Acute Myocardial Infarction

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Introduction: Acute Myocardial Infarction (AMI) is a medical emergency despite impressive advancement in diagnosis and management. The purpose of this study was to investigate and correlate C-reactive protein (CRP), an inflammatory marker and serum Malondialdehyde (MDA), an index of lipid peroxidation in Acute Myocardial Infarction. Materials and Methods: The study was conducted in 80 subjects divided in two groups, 50 patients with AMI (35 years to 81 years) and 30 age and sex matched healthy control. Serum CRP & Serum MDA readings were taken on day 1, 3, 5 and at the time of discharge (8±1days) from the onset of symptoms which is found statistically significant on all the days as compared to the control. Results: CRP and MDA has a definite pattern in AMI, CRP level stars to decline by 3rd day and MDA levels starts to decline by 5th day. There is also a significant positive correlation between CRP and MDA on day 1. Conclusion: These results suggest that inflammation and oxidative stress may play important role in acute myocardial infarction; hence, monitoring of these parameters is highly recommended which may be beneficial to improve the patient’s outcome following AMI.
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  • 2
86-93
  • English

REFERENCES

References: 

1. Alpert Js. Thygesen K, Antman E,
Bassand JP, Myocardial Infarction
redefined-a consensus document of The
joint European Society of
Cardiology/American College of
Cardiology Committee for the redefinition
of myocardial infarction. J Am Coll
Cardiol. 2000;36:959.
2. Enas EA, Yusuf S, Mehta JL, Prevalence
of Coronary Artery Disease in Asian
Indians. Am. J. Cardiol 1998; 70; 945-
949.
Indian Journal of Basic & Applied Medical Research; March 2012: Issue-2, Vol.-1, P. 86-93
92
www.ijbamr.com
3. Nijmeijer R, Lagrand WK, Lubbers YT,
C-reactive protein activates complement
in infarcted human myocardium. Am J
Pathol. 2003;163:269–275
4. Sabatine MS, Morrow DA, de Lemos JA,
Multimarker approach to risk
stratification in non-ST elevation acute
coronary syndromes: simultaneous
assessment of troponin I, C-reactive
protein, and B-type natriuretic peptide.
Circulation. 2002; 105:1760–1763.
5. Torzewski M, Rist C, Mortensen RF,
Zwaka TP, Bienek M, Waltenberger J,
Koenig W, Schmitz G, Hombach V,
Torzewski J, C-reactive protein in the
arterial intima: Role of C-reactive protein
receptor-dependent monocyte
recruitment in atherogenesis. Arterioscler
Thromb Vasc Biol 2000;90:2094–2099.
6. Pasceri V, Cheng JS, Willerson JT, Yeh
ET, Chang J, Modulation of C-reactive
protein-mediated monocyte
chemoattractant protein-1 induction in
human endothelial cells by antiatherosclerosis
drugs. Circulation 103:
2531–2534, 2001.
7. Wang CH, Li SH, Weisel RD, Fedak
PW, Dumont AS, Szmitko P, Li RK,
Mickle DA, Verma S: C-reactive
protein upregulates angiotensin type
1 receptors in vascular smooth
muscle. Circulation. 2004; 107:
1783–1790.
8. Suwimiol jetawattana, Free radical &
radiation Biology; Malondialdehyde
(MDA) a lipid oxidation product.
Spring 2005; 77: 222.
9. Kappus H, Lipid peroxidation :
Mechanisms, analysis , enzymalogy
and biological relevance.In : Sies H,
ed.Oxidative stress .London ,
England: Academic press, 1985;273-
310.
10. Satoh K, Serum lipid peroxide in
cerbrovascular disorders determined
by new colorimetric method. Clin
Chim Acta. 1978; 90:37—43.
11. Kushner I, Broder ML, Karp D.
Control of the acute phase response.
Serum C-reactive protein kinetics
after acute myocardial infarction. J
Clin Invest. 1998; 61:235–242.
12. Justo Aznar,m Teresa santos,t Juana
valles,t Jesus sala: J Clin Pathol
1983;36:712-715
Indian Journal of Basic & Applied Medical Research; March 2012: Issue-2, Vol.-1, P. 86-93
93
www.ijbamr.com
13. Yang huijian, lian huan, tian xiangting,
Guangdong people's hospital,guangzhou,
study on correlation of plasma
malondialdehyde and high sensitive creactive
protein in acute myocardial
infarction. Modern Hospital jour.2011;07-
013 .

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