Buradasınız

Anasayfa » Content

Study of C - reactive protein and intraocular pressure in Type 2 Diabetics

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2014

Key Words:

Author Name
Abstract (2. Language): 
Diabetes and its complications are spreading like an epidemic. Studies have proven diabetes as a subclinical inflammatory state. The present research was undertaken to study whether this inflammatory status in diabetics affects the eye. 50 Type 2 diabetic male subjects in the age group of 45 to 60 years, having duration of Diabetes more than 6 years were compared against 50 healthy age matched controls. Anthropometric measurements and Intraocular pressure of the subjects and controls were taken after which there blood investigations were done which included Fasting, Post meal blood sugar, Glycosylated hemoglobin, C-Reactive protein. The values obtained for weight, BMI, Fasting, Post meal blood sugar, Glycosylated hemoglobin, C-Reactive protein were significantly higher in Type 2 Diabetics as compared to controls. A positive linear correlation was found between glycated hemoglobin and C – Reactive protein levels suggesting that the long term glycemic status influence the C – Reactive protein levels. The significantly higher values of intraocular pressure in Type 2 Diabetics and positive linear correlation between glycated hemoglobin and intraocular pressure suggests that the long term glycemic status influences the intraocular pressure and that it may be one of the factors that might have led to increase in intraocular pressure. Thus improving blood sugar control may help improve intraocular pressure control. No correlation was found between intraocular pressure and C – Reactive protein levels suggesting that though diabetics are at increased risk of raised intraocular pressure, the subclinical inflammatory status associated with diabetes might not have contributed to it.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-study-c-reactive-protein-and-intraocular-pressure-type-2-diabetics.pdf
  • 3
197
203
  • English

REFERENCES

References: 

1. Hong Ding Chris R Triggle. Endothelial cell dysfunction & the vascular complications associated with type 2
diabetes: assessing the health of endothelium. Vascular health &risk management 2005:1(1)55-71.
2. Park, K. Text Book of Preventive and Social Medicine Jabalpur;M/S Banarsidas Bhanot Publishers 2005,pp- 311-
315.
3. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end products:a review. Diabetologica 2001; 44:129-146.
4. Thornalley PJ. Cell activation by glycated proteins: AGE receptors, receptor recognition factors and functional
classification of AGEs. Cell Mol Biol 1998;44:1013-1023.
5. Kathryn CB Tan, Wing- sun Chow, Sideny Tam, Richard Bucala, John Betteridge. Association between acute
phase reactants and advanced glycation end products in type 2 diabetes. Diabetes Care January 2004;27:223-228.
6. Vlassara H, Brownlee M, Manogue KR, Dinarello CA, Pasagian A. Cachectin\TNF and IL-1 induced by glucose
modified proteins: role in normal tissue remodeling. Science 1998;240:1546-1548.
7. E Wright JR, JL Scism-Bacon and LC Glass. Oxidative stress in type 2 diabetes: the role of fasting and
postprandial glycaemia. Int J Clin Pract. March 2006;60(3):308–314.
8. Caparevic Z, Kostic N, Ilic S, Stojanovic D, Ivanovic AM. Oxidized LDL and C-reactive protein as markers for
detection of accelerated atherosclerosis in type 2 diabetes. Med Pregl 2006 Mar-Apr,59(3-4):160-4.
9. Hala El-Mesallamy, Salwa Suwailem, and Nadia Hamdy: Evaluation of C - reactive protein, Endothelin-1,
Adhesion molecule(s), and Lipids as Inflammatory markers in type 2 diabetes mellitus patients. Mediators
inflamm 2007; 2007: 73635
10. Klein BE, Klein R, Moss SE. Intraocular pressure in diabetic persons. Ophthalmology 1984 Nov;91(11):1356-60
11. Dielemans I, DeJong PTVM, Stolk R, et al. Primary open angle glaucoma, intraocular pressure and Diabetes
mellitus in the general elderly population:The Rotterdam Study. Ophthalmology 1996; 103:1271-1275.
12. Wu SY, Leske MC. Association with intraocular pressure in the Barbados eye study. Arch Ophthalmol.
1997;115:1572-1576.
13. Clark CV, Mapstone R. The prevalence of diabetes mellitus in the family history of patients with primary
glaucoma. Doc Ophthalmol. 1986;62:161–163.[Pubmed]
0
5
10
15
20
25
0 2 4 6 8 10 12 14
IOP in mmHg
Glycated Haemoglobin in %
Scatter Diagram No. 2 : Correlation between Glycated
Haemoglobin and IOP
202
Indian Journal of Basic and Applied Medical Research; June 2014: Vol.-3, Issue- 3, P. 197-203
200
www.ijbamr.com P ISSN: 2250-284X , E ISSN : 2250-2858
14. Christiansson, J. Intraocular pressure in diabetes mellitus. Acta. Oph., 39, 155, 1961.
15. Hollows FC, Graham PA. Intraocular pressure, glaucoma and glaucoma suspects in a defined population. Br J
Ophthalmol 1966; 50:570-586.
16. Davies PD, Duncan G, Pynsent PB, Arber DL, Lucas VA. Aqueous humor concentration in cataract patients and its
effect on the lens. Exp Eye Res 1984;39:605-09.
17. Tsuyoshi Sato and Sayon Roy. Effect of high glucose on fibronectin expression and cell proliferation in trabecular
meshwork cells. Investigative Ophthalmology and visual Science January 2002,vol. 43, No.1:170-175
18. Alvarado J, Murphy C, Juster R. Trabecular meshwork cellularity in primary open-angle glaucoma and
nonglaucomatous normals. Ophthalmology 1984;91:564-79.
19. Dana EK, Arch GM, Thomas AB and William SP. C-Reactive Protein and Glycemic Control in Adults With
Diabetes. Diabetes Care 2003; 26:1535-1539
20. Pfutzner A, Forst T. High sensitivity C-reactive protein as cardiovascular risk marker in patients with Diabetes
mellitus. Diabetes Technol Ther 2006 Feb;8(1):28-36.
21. Fichtlscherer S, Rosenberger G, Walter DH, Breuer S, Dimmeler S, Zeiher AM. Elevated C-reactive protein levels
and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 2000;102:1000–1006.
22. Farnaz Memarzadeh, Mei Ying-Lai, Stanley PA, Rohit Varma, and Los Angles Latino Eye Study Group.
Associations with Intraocular Pressure in Latinos: The Los Angeles Latino Eye Study, Am J Ophthalmol
2008;146(1):69-76.
23. Dielemans I, DeJong PTVM, Stolk R, et al. Primary open angle glaucoma, intraocular pressure and Diabetes
mellitus in the general elderly population:The Rotterdam Study. Ophthalmology 1996; 103:1271-1275.
24. Simone de Voogd, Roger CW Wolfs, Nomdo MJ, Jacqueline CM Witteman, Albert Hofman and Paulus TVM de
Jong. Atherosclerosis, C - reactive protein, and Risk for Open-Angle Glaucoma: The Rotterdam Study.
Investigative Ophthalmology and Visual Science sept. 2006,Vol. 47,No.9.

Thank you for copying data from http://www.arastirmax.com