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Şizofreni olgularında sol temporal lob proton manyetik rezonans spektroskopi bulguları

Proton magnetic resonance spectroscopy findings in the left temporal lobe of patients with schizophrenia

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2009

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Abstract (2. Language): 
Most of the symptoms of schizophrenia bring mind the symptoms of temporal area illnesses. 1 H-MRS studies carried out on schizophrenia patients focused especially on temporal and frontal lobes and basal ganglions. In this study, it was aimed to detect the 1 H-MRS findings of left temporal lobe in patients with Schizophrenia. Twenty seven patients diagnosed to have schizophrenia according to the criteria of DSM-IV and 10 healthy control cases were included in the study. The symptoms of schizophrenia were assessed with the Brief Psychiatric Rating Scale, The Assessment of Positive Symptoms Scale and The Assessment of Negative Symptoms Scale. All the spectroscopic images were collected with the same MRI device. Patients with schizophrenia had a higher level of creatine and a lower level of Nacetyl aspartate/creatine ratio when compared to the control group. Other metabolite levels in the study group were similar to those of the control group. In addition, there was no significant correlation between the metabolite levels and clinical characteristics and scale ratios. The findings in this study indicate a hipometabolic state and loss of neurons due to the depletion of N-acetyl aspartate/creatine levels in the left temporal lobes of the Schizophrenia patients. Our results support those who advocate the theory that Schizophrenia is a neurodevelopmental disorder.
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Abstract (Original Language): 
Şizofreninin birçok belirtisi, temporal bölgeye ait bir hastalığın belirtilerini de akla getirmektedir. Şizofreni hastalarında yapılan 1 H-MRS çalışmaları, özellikle temporal, frontal loblar ve bazal gangliyonlar üzerine yoğunlaşmıştır. Bu çalışmada, şizofreni olgularında sol temporal lob 1 H-MRS bulgularının saptanması amaçlanmıştır. Araştırmaya DSM-IV ölçütlerine göre şizofreni tanısını karşılayan 27 şizofreni ve 10 sağlıklı kontrol olgusu alınmıştır. Şizofreninin belirtileri Kısa Psikiyatrik Derecelendirme Ölçeği, Pozitif Belirtileri Değerlendirme Ölçeği ve Negatif Belirtileri Değerlendirme Ölçeği ile değerlendirilmiştir. Spektroskopik görüntülerin hepsi, aynı MR cihazında elde edilmiştir. Şizofreni olgularının kontrol grubuna göre daha yüksek kreatin ve daha düşük N-asetil aspartat/kreatin değerlerine sahip olduğu görülmüştür. Diğer metabolit düzeylerinin kontrol grubu ile benzer olduğu saptanmıştır. Ayrıca, metabolit düzeyleri ile klinik özellikler ve ölçek puanları arasında anlamlı bir ilişki olmadığı bulunmuştur. Bu çalışmada elde edilen bulgular şizofreni olgularının sol temporal loblarında N-asetil aspartat/kreatin düzeylerinin azalmasına bağlı hipometabolik bir durumun ve nöron kaybının olabileceğini göstermektedir. Sonuçlar şizofreninin nörogelişimsel bir bozukluk olduğu kuramını savunanları desteklemektedir.
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  • 3
152-157
  • Turkish

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