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Bir Lupus Nefriti Hastasında Siklofosfamid Tedavisi Sonrası Gelişen Geri Dönüşümlü Posterior Lökoensefalopati Sendromu

Development of Reversible Posterior Leukoencephalopathy Syndrome after Cyclophosphamide Treatment in a Patient with Lupus Nephritis

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2011
DOI: 
DOI 10.5262/tndt.2011.1001.19

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Renal involvement in systemic lupus erythematosus is a frequent and serious complication that significantly increases morbidity and mortality. Despite all studies and usage of new drugs, treatment of lupus nephritis continues to be a problem. Diffuse proliferative lupus nephritis has a poor prognosis and aggressive treatment must be undertaken. Cyclophosphamide is commonly used in treatment despite its side effects. Reversible posterior leucoencephalopathy syndrome is a clinico-radiological syndrome manifested by blood pressure elevation, headache, visual disturbances, confusion, seizures and sometimes focal neurological signs that can develop due to usage of cytotoxic drugs. We present a case of lupus nephritis in which reversible posterior leucoencephalopathy syndrome developed after intravenous cyclophosphamide administration and recovered spontaneously by symptomatic treatment in this article.
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Abstract (Original Language): 
Sistemik lupus eritematozus’ta böbrek tutulumu, morbidite ve mortaliteyi anlamlı derecede arttıran sık ve ciddi bir komplikasyondur. Lupus nefritinin tedavisi tüm çalışmalara ve yeni ilaçların kullanılmasına rağmen önemli bir problem olmaya devam etmektedir. Diffüz proliferatif lupus nefriti en kötü prognoza sahiptir ve agresif tedavi edilmesi gerekmektedir. Tedavide istenmeyen yan etkileri olmasına rağmen siklofosfamid yaygın olarak kullanılmaktadır. Reversibl (geri dönüşümlü) posterior lökoensefalopati sendromu sitotoksik ilaçların kullanılmasına bağlı olarak ortaya çıkabilen, klinik olarak ani kan basıncı yüksekliği ile birlikte baş ağrısı, görme bozuklukları, konfüzyon ve nöbetler ile karakterize, bazen fokal nörolojik bulguların da eşlik ettiği bir klinikoradyolojik sendromdur. Yazımızda lupus nefriti tanısı alan, damardan siklofosfamid uygulaması sonrası geri dönüşümlü posterior lökoensefalopati sendromu gelişen ve semptomatik tedavi ile kendiliğinden düzelen bir olgu sunulacaktır.
FULL TEXT (PDF): 
PDF icon arastrmx_172977_20_pp_104-107.pdf
  • 1
104-107
  • Turkish

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