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Lupus Nefritini n Tedavisi

Treatment of Lupus Nephritis

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Abstract (2. Language): 
Renal involvement is the cause of major mortality and morbi¬dity of systemic lupus erythematosus (SLE) disease. Although regi¬mes including pulse cyclophosphamide and corticosteroid are the most effective treatment modalities, they are not ideal for toxicity. The increase in neoplasm risk, infections and gonadal toxicity are the major concerns about cyclophosphamide. While choosing the treatment of severe lupus nephritis, risk benefit ratio should be thought individually. Clinical status, activity degree, chronicity in renal histology, tolerability of the patient, presence of infection, cytope-nia, extrarenal involvement should be evaluated in detail. The treatment of lupus nephritis was discussed with this review.
Abstract (Original Language): 
Renal tutulum , sistemik lupus eritematozus (SLE) hastalığının majör mortalite ve morbidite sebebi olmaktadır. Tedavide kullanılan en etkin rejimlerin puls siklofosfamid ve steroid içerenler olmasına karşılık, bunlar toksisite bakımından ideal değildir. Neoplazi riskinde, infeksiyonlarda ve gonadal toksisitede artış siklofosfami-de karşı olan majör kaygılardır. Ciddi derecedeki lupus nefritinin tedavisi seçilirken, risk ve yarar oranı bireysel olarak iyi düşünülmelidir. Klinik durumu, aktivite derecesi, renal histolojide kronisite, hastanın tolerasyonu, infeksiyon varlığı, sitopeni, ekstrarenal tutu¬lum varlığı ayrıntılı olarak değerlendirilmelidir. Bu derleme ile lupus nefritinin tedavisi tartışılmıştır.
FULL TEXT (PDF): 
71-76

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