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Tavşanlarda topikal penisilin uygulaması ile oluşturulan deneysel epilepsi sonucu beyin eser element değişiklikleri

The brain trace elements Changes in experimental epilepsy induced by topical penicillin application in rabbits

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aim of this study was to investigate the role of zinc (Zn) and copper (Cu) on physiopathology of epilepsy. For this purpose, experimental epilepsy model was formed by penicillin application in rabbits. Forty rabbits were used and divided into equal two groups as experimental epilepsy group and control group. Screw electrodes were applied in four different cortical regions in rabbits. Electrophysiological and clinical seizures were observed after 60000 IU penicillin dropped in posterior sensory motor area, and their electrocorti-gograms were recorded. The animals were decapitated two hours later and their brains were evaluated. Brains were homogenized in nitric acid solution and the levels of Zn and Cu were measured using atomic absorption device. We found that Zn levels in rabbits induced epilepsy were lower and Cu levels were higher than control groups . But these differences were not statistically significant. In conclusion, topical penicillin application had no significant effect Zn and Cu levels in brain of rabbits.
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Abstract (Original Language): 
Bu çalışmanın amacı çinko (Zn) ve bakırın (Cu ) epilepsi fizyopatolojisindeki rollerini araştırmaktır. Bunun için, tavşanlarda topikal penisilin uygulaması ile deneysel epilepsi oluşturuldu. Çalışma 20'si deneysel epilepsi grubu ve 20'si kontrol grubu olmak üzere 40 adet tavşan üzerinde gerçekleştirildi. Tavşanların dört farklı korteks alanına vida elektrotlar yerleştirildi. Posterior sensorimotor alana 60 bin ünite potasyum penisilin G damlatılması sonrasında elektrofizyolojik ve klinik nöbet gözlendi ve elektrokortigogramları kaydedildi. Nöbet gözlendikten iki saat sonra tavşanlar dekapite edilerek beyinleri çıkarıldı. Beyinler nitrik asitle homoj-enize edildikten sonra Zn ve Cu düzeyleri atomik absorbsiyon aleti ile ölçüldü. Epilepsi oluşturulan gruptaki Zn miktarlarında düşüklük, Cu miktarlarında ise yükseklik tespit edildi. Fakat bu değişiklikler istatistiksel olarak anlamlı değildi. Sonuç olarak tavşanlarda topikal penisilin uygulamasının beyin Zn ve Cu düzeylerini anlamlı düzeyde etkilemediği kanaatine varıldı.
FULL TEXT (PDF): 
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  • 4
10-13
  • Turkish

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