You are here

Home » Content

Yüksek doz florun sıçan dokularına etkisi

The effect of high dose florid on rat tissue

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
İn our study, We have aimed to search the findings seen on the tissue specimens taken from the liver, kidney, ovary, testis and pancreas of many rats that have been poisoned by long- term high doses of florid. Twenty rais which beiong to VVistar Albino species were being equally separated into two groups, one is as the experimental group, the other as the control group [10 (5 male + 5 female) * 10 (5 male + 5 female)]. For a 17 weeks time, dhnking water consisting of 1 ppm florid to control group and consisting of 150 ppm florid to experimental group has been given. Pieces taken from the tissue specimens of the liver, kidney, spleen, ovary, testis and pancreas were being examined under the light microscope. İn the experimental group, the foilowing findings were being obtained: İn peripherai lobule of the liver, focal sinusoidal diiatations, in the portal area, lymphocyte infiitration; in hepatocytes a liftle hydropic and vacuolar degeneration; in the kidney either in proximal or distal tubule, a little hydropic degeneration were being determined. There hasn't been seen any pathology in the spleen, ovary, testis and pancreas sections taken from the experimental group. As a result, it was determined that high doses of florid causes minimal structural changes phmahly in the liver tissue and then in the kidneys, besides it has no considerable effect on the testis, ovary, spleen and pancreas tissue.
Bookmark/Search this post with
Abstract (Original Language): 
Çalışmamızda, yüksek dozda uzun süreli flor zehirlenmesi oluşturulan sıçanların karaciğer, böbrek, dalak, ovaryum, testis ve pankreas doku örneklerinde görülen etkileri araştırmayı amaçladık. VVistar Albino cinsi 20 adet sıçan eşit olarak deney ve kontrol grubu olarak iki gruba [10(5 erkek + 5 dişi) +10(5 erkek + 5 dişi)] ayrıldı. Kontrol grubunun içme suyunda flor oranı 1 ppm olacak şekilde, deney grubuna ise 150 ppm flor içirecek şekilde 17 hafta süreyle verildi. Karaciğer, böbrek, dalak, ovaryum, testis ve pankreas doku örneklerinden alınan parçalar ışık mikroskobunda değerlendirildi. Deney grubunda; karaciğerde lobul periferinde foka! sinuzoidal dilatasyonlar, por-tal alanda yer yer lenfosit infiltrasyonu, hepatositlerde az miktarda hidropik ve vakuoler dejenerasyon gözlendi. Böbrekte ise, gerek proksimal gerekse distal tubuluslarda hafif hidropik dejenerasyon tespit edildi. Deney grubun¬daki dalak, ovaryum, testis ve pankreas kesitlerinde ise herhangi bir patolojiye rastlanmadı. Yüksek doz verilen florun başta karaciğer olmak üzere daha sonra böbrek dokusu üzerinde minimal düzeyde yapısal değişikliklere yol açarken; testis, ovaryum, dalak ve pankreas dokusu üzerine ise önemli bir etkisinin olmadığı sonucuna varıldı.
FULL TEXT (PDF): 
PDF icon arastirmax-yuksek-doz-florun-sican-dokularina-etkisi.pdf
  • 4
213-221
  • Turkish

REFERENCES

References: 

1. Chavasieux P, Meunier PJ. Benefits and risks of fluo-ride supplements. Arc Pediatr 1995; 2: 568-572.
2. VValorı K.C. Enviromental Fluoride and Fluorosis in Mamal Rev.1981; 18: 77-90.
3. Blood D.C, Henderson J.A. Veterinary Medicine. 8th Edition, Ballrere, Tindall. London, 1990.
4. Smith GE. Fluoride and fluoridation. Soc. Sci Med 1988: 26: 451-462.
5. Shashi T, Sing JP. Pulmonary damage caused by fluo¬ride in rabbits during experimental fluorosis. APMİS 1988; 96: 333-6.
6. Shashi T. Histopathological changes in rabbit ovary during experimental fluorosis. Indiarı J Paihol Microbiol 1990; 33: 113-7.
7. Shashi T. Kaur D. Testicular proteins and DNA in experimental fluorosis. Indian J Pathol Microbiol 1992; 35: 351-6.
8. Tsunenari I. Kast A. Developmental and regressive changes in the testes of the Himalayan rabbit. Lab Anim 1992; 26167-179.
9. Sprando RL. Black TN, Ames MJ. Effect of intsıçanes-ticular injection of sodium fluoride on spermatogenesis. Food Chem Toxicol 1996; 34: 377-84.
10. Yuan SD, Song KQ, Xie QW, Lu FY. An experimental study of inhibition on lactation in fluorosis sıçans. Sheng Li Xue Bao 1991; 43: 512-7.
11. Susheela AK, Sharma YD. Chemical profile of blood in fluoride toxicity. III. Plasma fibrinogen levels in rabbit. Toxicol Eur Res 1981; 3: 105-7.
12. Kessabi M, Hamliri A, Braun JP. Experimental fluorosis in sheep: alleviating effects of aluminum. Vet Hum Toxicol 1986: 28: 300-4.

13. Kaminsky LS. Mahoney MC, Leach J. Melius J. Fluoride: benefits and risks of exposure. Crit Rev Oral Biol Med 1990; 1: 261-81.
14. Mattsson JL, Albee RR, Eisenbrandt DL, Chang LW. Subchronic neurotoxicity in sıçans of structural fumi-gant. sulfuryi fluoride. Neurotoxicol Tesıçanol 1988: 10: 127-33.
15. Lavrushenko LF, Trunov VI, Okunev VN. Morphofunctional characteristics of certain sıçan liver hepatocytic ulrastructures during prolonged exposure to sodium fluoride. Tsitoi Genet 1980; 14. 10-2.
16. Tsukamoto C, Towner J. Ethanol-İnduced İiver fibrosis in sıçans fed high-fat diet. Hepatology 1986; 6: 814-22.
17. Aslan R. Şekeroğİu MR. Serbest radikal türlerin mem-bran lipit peroksidasyonuna etkileri ve hücresel antiok¬sidan savunma. Sağlık. Bil. Derg. 1995; 2: 137-42.

18. Byung PY. Cellular defenses against damage from reac-
tive species. Physiological Revıews 1994: 74: 139-72.
19. Harris ED. Regulation of antioxidant enzymes. Faseb Jour 1992; 6: 2675-83.
20. Aslan R. Homeostatik mekanizmanın korunması ve sağalımda antioksidanlar. İlaç Tedavi Der. 1999: 8: 475-81.
21. Aslan R, Şekeroğİu MR. Blood Lipoperoxidation and antîoxidant enzymes in heathy individuals. J. Environ. Sci. Healh 1997; 32: 2101-9.
22. Thomas MJ, The role of free radicals and antioxidants:
How do we know that they are working ? Critical Rew. Food. Sci. And Nutrit 1995; 35: 21-39.
23. Greene DA. Acute and chronic complications of diabetes
mellitus in order patients. Am. J. Med. 1980; 80: 39-53.

Thank you for copying data from http://www.arastirmax.com