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Vertebral Kemik İliği T2 Relaksasyon Zamanının Osteoporozda Tanı Değeri

Diagnostic value of Vertebral Bone Marrow T2 Relaxation Time in Osteoporosis

Journal Name:

  • Uludağ Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2010

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Keywords (Original Language):

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Abstract (2. Language): 
The aim of this study was to evaluate the diagnostic value of T2 relaxation time measurements of lumbar vertebral marrow in osteoporosis. This study had institutional review board approval and all participants provided informed consent. Fifty-six female patients (age range from 50 to 65 years) with varying bone mineral densities (BMD) as documented with dual x-ray absorptiometry (DXA) were prospectively included in the study. According to the DXA results, the patients were grouped as normal, osteopenic and osteoporotic. The T2 relaxation time measurements (MR relaxometry) were performed with multi spin echo sequence at sagittal plane. The quantitative values were compared statistically with those obtained from DXA examinations. Kruskal-Wallis and Mann-Whitney-U tests were used for comparisons between groups. Eighteen subjects with normal bone density (mean T score, 0,39 ±1,13 [standard deviation]), 20 subjects with osteopenia (mean T score, -1,79±0,38), and 18 subjects with osteoporosis (mean T score, -3±0,5) were determined according to DXA results. Vertebral bone marrow T2 relaxation time value was 113.6 (min:max=104:124) in normal group, 114.2 (min:max=107:135) in osteopenic group, and 112.8 (min:max=102:121.4) in osteoporotic group. There was no statistically significant difference between T2 relaxation times of normal, osteopenic and osteoporotic vertebrae (p>0.05). In conclusion vertebral bone marrow T2 relaxation time is not a reliable parameter for prediction of vertebral BMD for female patients at 50-65 ages.
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Abstract (Original Language): 
Çalışmanın amacı osteoporozda, lomber vertebra kemik iliği T2 relaksasyon zamanının tanı değerini araştırmaktır. Aydınlatılmış onam formu ve etik kurul onayı tüm katılımcılardan alındı. “Dual x-ray absorptiometry” (DEXA)’ya göre değişken kemik mineral dansitesi (KMD) olan 56 hasta (50-65 yaşlar arası) prospektif olarak çalışmaya alındı. DEXA sonuçlarına göre hastalar normal, osteopeni ve osteoporoz olarak gruplandı. T2 relaksasyon zamanı (MR relaksometri), sagittal planda multi spin eko sekans ile yapıldı. Kantitatif değerler, DEXA sonuçlarına göre istatistiksel olarak karşılaştırıldı. Gruplar arası karşılaştırmada “Kruskal-Wallis” ve “Mann-Whitney-U” testleri kullanıldı. DEXA’ya göre 18 olgu normal kemik dansitesi (ortalama T skoru, 0,39 ±1,13 [standart sapma]), 20 olgu osteopeni (ortalama T skoru, -1,79±0,38) ve 18 olgu osteoporoz (ortalama T skoru, -3±0,5) olarak değerlendirildi. Vertebral kemik iliği T2 relaksasyon zamanı değerleri normal olgularda 113.6 (min:max=104:124), osteopenide 114.2 (min:max=107:135), osteoprozda 112.8 (min:max=102:121.4) idi. T2 relaksasyon zamanı bakımından gruplar arasında anlamlı farklılık bulunmadı (p>0.05). 50-65 yaş grubundaki kadın hastalarda, vertebral kemik iliği T2 relaksasyon zamanı, KMD’nin öngörülmesinde güvenilir bir parametre değildir.
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  • 2
49-53
  • Turkish

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