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Kronik Böbrek Hastalığında Magnezyumun Önemi: Yeni Görüşler

The Importance of Magnesium in Chronic Kidney Disease: New Aspects

Journal Name:

Publication Year:

DOI: 
10.5262/tndt.2014.1002.01
Abstract (2. Language): 
Magnesium is one of the 11 most abundant elements in the human body and it is required for the action of over 300 enzymes. It is the most common intracellular, bivalent cation. It is located in quite important structures from DNA/RNA to ATP. It interacts with negatively charged ions to provide an allosteric effect and therefore plays the role of a bridge in connecting different molecules. It is mostly found in dark green vegetables, the chlorophyl complex and unprocessed cereals. The current environmental pollution and the increased consumption of refined products cause serious problems with Mg uptake. Despite considerable advances over the last decades, cardiovascular diseases exact a very high toll as the leading cause of death in Western societies. This is mainly the result of the increasing prevalence of atherosclerosis, related to the aging of the population, the increase in diabetes and obesity, unhealthy diets, sedentary lifestyle, and particularly hyperlipidemia and hypertension. Chronic kidney diseases are quite common in the population at present and are associated with serious mortality and morbidity. Our aim in this review was to investigate the effect of Mg on endothelial dysfunction, atherosclerosis and CKD.
Abstract (Original Language): 
Vücutta en çok bulunan 11 elementten biri olan ve üç yüzden fazla enzimatik reaksiyonda görev almakta olan Magnezyum (Mg); en sık görülen hücre içi, bivalen katyondur ve ATP yapısından DNARNA yapısına kadar oldukça önemli yapılarda bulunmaktadır. Negatif yüklü iyonlar ile etkileşime girerek allosterik etki sağlar ve farklı moleküllerinin birbirine bağlanmasında köprü rolü oynar. Çoğunlukla koyu yeşil renkli sebzelerde, klorofil kompleksi içerisinde ve işlenmemiş hububatta bol miktarda bulunmaktadır. Ancak gerek çevre kirliliği gerekse artmış rafine ürünlerin tüketimi nedeniyle günümüzde magnezyumun doğal yollardan alınımında ciddi sorunlar bulunmaktadır. Son 10 yıl içinde kayda değer gelişmelere rağmen kardiyovasküler hastalıklar hala Batı ülkelerinde önde gelen ölüm nedenidir. Bunun ana nedeni popülasyonun yaşlanması, diyabet ve obezitenin artması, sağlıksız beslenme, sedanter yaşam, hiperlipidemi ve hipertansiyon gibi faktörlere bağlı olarak aterosklerozun artmasıdır. Yine günümüzde kronik böbrek hastalıkları oldukça yaygın görülmekte, ciddi mortalite ve morbidite ile birliktelik göstermektedir. Bu derlemede magnezyumun özellikle endotel disfonksiyonu, ateroskleroz ve kronik böbrek hastalıklarında; çokta fazla bilinmeyen yönlerine ışık tutulmaya çalışılacaktır.
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