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Akraba evliliklerinin doğumsal kalp defektlerinin sıklığına etkisi

The influence of consanguineous marriage upon the frequency of congenital heart defects

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Three hundred seventy patients with congenital heart defects (CHD) who were admitted to Pedİatric Cardiyology Unit of Selçuk University, Meram Medical School Hospital, between September 1999 and September 2001, were evaluated. Ventricular septal defect was the most common type of CHD and it was follovved by atrial septal defect as in literatüre. Consanguinİty marriage was detected as 30.0 % among the parents of the patients with CHD. This ratio was significantly higher than the ratio detected from the healthy control group. As we investigated the degree of relativity among the parents of the patients with CHD, we found that the first cousin marriage was higher than the far consanguinity marriage. These findings indicated that first cousin marriage could increase the occurence of CHD among the offsprings.
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Abstract (Original Language): 
Selçuk Üniversitesi Meram Tıp Fakültesi Pedİatrik Kardiyoloji Bİİİm Dalına Eylül 1999-Eylül 2001 tarihleri arasında başvuran ve doğumsal kalp defekti (DKD) tanısı alan 370 olgu incelendi. Literatüre uygun olarak en sık rastlanan DKD'nİn ventriküier septal defekt olduğu ve bunu atriyal septal defektin izlediği görüldü. DKD'li olguların ebeveyn-lerinde akraba evliliğine % 30.0 oranında rastlandı. Bu oran sağlıklı kontrollere göre anlamlı olarak daha yüksek¬ti. Ebeveynleri akraba olan DKD'li olguların ebeveynleri arasındaki akrabalık derecesi araştırıldığında, 3.derece akraba (birinci kuzen) evliliklerine, uzak akraba evliliklerinden anlamlı olarak daha fazla rastlandığı tespit edildi. Sonuçlarımız, özellikle 3. derece akraba evliliklerinin DKD'li çocuğa sahip olma riskini artırdığını telkin etmektedir.
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  • 3
167-170
  • Turkish

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