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ASTIM BRONŞÎYALE' LİLERDE SERUM EOZİNOFİLİK KATYONİK PROTEİN DÜZEYİNİN KLİNİK VE FONKSİYONEL PARAMETRELER İLE İLİŞKİSİ

The comparison of serum eosinophü cationic protein levels with clinical and functional parameters ın asthma bronchiale patients

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 1999

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
cationic protein levels with clinical and functional parameters ın asthma bronchiale patients. We reported this study in order to determine the relation between serum eosinophil cationic protein (ECP) levels, and classical diagnostic and follow up methods in asthmatic patients. Seventeen patients with mild asthma as first group, 19 patients wİth moderate asthma as se-cond group, a total of 26 female and 10 male, and 19 healthy persons (14 female, 5 male) in the same age range as third group were İncluded in the study. Atopy signs and symptoms, physİcal and radiological examination findings,peripheral eosinophil counts, total and specifıc lgE levels, prick skin tests and pulmonary function tests were compared with serum ECP levels. In 789 of study group cases (28/36) prick skin tests and specifıc lgE levels were positive. Sen-sitivity against house dust mite antigen was determined by prick skin test in 67% of patients (24/36) and by specİfic lgE level measurement in 69% of patients (25/36). There was no signi-ficant correlation between serum ECP levels and severity and duration of asthma, physical and radiological examination findings, total and specifıc lgE levels, and allergic prick test. On the other hand, serum ECP levels showed a significant correlation wİth peripheral eosinophil counts (>400/mm3, ECP: 36.08+22.94; <400/mm3, ECP: 18.93±14.88) p=0.034 r=0.323, where as adverse relation was observed between serum ECP levels and pulmonary function tests (FEV1%-~ECP p=0.043, r=-0.375; FEV1/FVC%--ECP p=0.018, r—0.449) İn conelusion serum ECP level shows activation of eosinophils, is specific marker of inflam-matory airway obstruction and may be of help in therapeutİc approach in ehronic asthma
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Abstract (Original Language): 
Astım bronşiyale'li olgularda serum eozinofil katyonik proteinin (ECP) klasik tanı ve izleme yöntemleri ile ilişkisini belirlemek amacı ile bu çalışmayı yaptık. Çalışmamızaf I. grupta hafif astımlı 17, ILgrupta orta derecede astımlı 19 toplam (26 kadın, 10 erkek) 36 olgu ve ffl.grupta aynı yaş grubunda (14 kadın, 5 erkek) 19 sağlıklı kontrol olgusu alındı. Atopi belirti ve bulguları,fizik muayene ve radyolojik bulguları, kan eozinofil sayıları, total ve spesifik lgE, prick deri testleri ve solunum fonksiyon testleri ile serum ECP düzeyleri karşılaştırıldı. Çalışma grubunda; olguların % 78' inde (28/36) spesifik lgE pozitifliği, %78'inde (28/36) prick deri testi pozitifliği saptandı. 24 olguda (% 67) prick deri testi ile 25 olguda (%69) spesifik lgE ölçümü ile ev tozu akan duyarlılığı saptandı. Serum ECP düzeyi ile astım şiddeti ve süresi, fizik muayene ve radyolojik bulgular, total ve spesifik lgE, allerjik prick deri testleri arasında korelasyon bulunamadı. Kan eozinofil sayısı ile pozitif (>400/mm3; ECP: 36.08 ± 22.94)-(>400/mm3; ECP: 18.93 ± 14.88) p=0.034, r= 0.323, solunum fonksiyon testleri ile negatif (FEVl%-ECP;p-0.043, r= 0.375, FEV1/FVC-ECP;=0.018, r=-0.449) korelasyon saptm-dı. Serum ECP düzeyi eozinofil aktivasyonunu yansıtan inflamatuar hava yolu obstrüksiyonunun spesifik bir belirtecidir. Serum ECP' si kronik astımın tedavi ve izlemesinde yönlendirici olabilir.
FULL TEXT (PDF): 
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  • 2
149-155
  • Turkish

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