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SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1, 3, 5 - OXADIAZINE AND 1, 3, 4 OXADIAZOLE COMPOUNDS FROM 4-CHLORO-2-HYDROXYBENZOIC ACID HYDRAZIDE

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

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Abstract (2. Language): 
4-chloro-2-hydroxy benzoic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-chloro-2-hydroxy benzoic acid arylidene hydrazides (2a-h) in good yields. Cyclocondensation of compounds (2a-h) with benzoyl isothiocynate and acetic anhydride yields respectively of 4-chloro-2-Hydroxy - N - (2-Substituted Phenyl)-6-Phenyl-4-Thioxo-2H-1,3,5,-Oxadiazin -3(4H)-Yl) Benzamide (3a-h) and 4-chloro-1-(5-(2-Hydroxyphenyl)-2-(Substituted Phenyl)-1,3,4-Oxadiazole-3) (2H)-yl)ethane (4a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.
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  • 2
373-384
  • English

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