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ANTILITHIATIC ACTIVITY OF SACCHARUM SPONTANEUM LINN. ON ETHYLENE GLYCOL - INDUCED LITHIASIS IN RATS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The ethanolic extract of roots of Saccharum spontaneum Linn. Was evaluated for its antilithiatic activity in rats. Lithiasis was induced by oral administration of ethylene glycolated water (0.75%) in adult male wistar albino rats for 28 days. The ionic chemistry of urine was altered by ethylene glycol (EG), which elevated the urinary concentration of calcium, oxalate, urea, uric acid and creatinine. However treatment with ethanolic root extract of S. Spontaneum (200 and 300 mg / kg body weight) in group III and IV significantly (p<0.05) reduced the elevated level of these ions in urine. Also, it elevated concentration of urinary magnesium, which is considered as one of the inhibitors of crystallization. The levels of serum calcium, oxalate, phosphorus, magnesium and protein were significantly increased (p < 0.05) in urolithiatic rats. Treatment with plant extract restored the levels and it brought back the values to near normal range in urolithiatic rats. All these observations revealed that ethanolic root extract of S. Spontaneum has curative effect on stone formation induced by ethylene glycol.
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  • 5
338-550
  • English

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REFERENECE
Research Article ISSN: 2277-8713
Sathya M, IJPRBS, 2012; Volume 1(5): 338-350 IJPRBS
Available Online At www.ijprbs.com
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