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TRANSDERMAL DRUG DELIVERY SYSTEM AS PROMINENT DOSAGE FORMS FOR THE HIGHLY LIPOPHILIC DRUGS

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
An ideal dosage form would be maintaining the drug concentration in the blood at a constant level nearly coinciding with the minimum effective concentration (MEC) of drug throughout the treatment period. This leads to the concept of the controlled drug delivery. The primary objective of controlled drug delivery is to ensure safety and efficacy of the drugs as well as patients compliance. TDDS is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through skin in a predetermined and controlled rate. At present, the most common route for the delivery of drugs is the oral route. While this has the notable advantage of easy administration, it also has significant drawbacks, namely poor bioavailability due to hepatic first pass metabolism and tendency to produce rapid blood level spikes, leading to a need for high and/ or frequent dosing, which can be inconvenient. To improve such characters transdermal drug delivery system (TDDS) was emerged which will improve the therapeutic efficacy and safety of drugs by more precise (i.e. site specific) placement within the body thereby reducing both the size and number of doses. Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy.
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REFERENCES

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