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FORMULATION AND EVALUATION OF BILAYER FLOATING TABLET FOR GASTRIC RETENTION

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The present investigation concerns the development and evaluation of floating tablets of Ciprofloxacin hydrochloride which, after oral administration, are designed to prolong the gastric residence time and increase drug bioavailability. Bilayer floating tablets comprised two layers, immediate release and controlled release layers. The immediate release layer comprised sodium starch glycolate as a super disintegrant and the controlled release layer comprised HPMC K15M and Carbopol 934P as release retarding polymers. Sodium bicarbonate was used as a gas generating agent. The controlled layer was compressed and powders of the immediate release layer were added to it then both layers were compressed using a single punch tablet machine. Direct compression method was used for formulation of the bilayer tablets. The tablets were evaluated for hardness, thickness, friability, Drug content, swelling index, floating lag time, floating duration and in vitro drug release. Final formulation released approximately 93% drug in 12 h in vitro, while the floating lag time was 10 sec, because of prompt disintegration of the fast releasing layer and the enhanced rate of dissolution of Ciprofloxacin hydrochloride from the system
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