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Çocuklardaki tedaviye dirençli konvülziyonlarda yeni antiepileptik ilaçlar

New antiepileptic drugs in intractable seizures in childhood

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Abstract (2. Language): 
the childhood intractable seizures: West Syndrome. Tennox-Gestaut Syndrome and childhood myoclonic epilepsy are entities with poor prognosis. Tour new antiepileptic drugs presented in this review are generally accepted as alternative drugs for these, h'elbamate. (iabapentin, Tamotrigine and \'igabatrin show their activity <m neurotransmitters in the central nervous system. Generally, they reduce the frequency of seizures more ıhan 50"-!, in 2()-h()% ol patients, and stop the seizures in "% of patients. 'The common disadvantage of these drugs is high cost /Journal of Turgut Özal Medical Center 2(1): 114-119.1995/
Abstract (Original Language): 
Çocukluk çağında pr agnozi ar m m kötülüğü ile bilinen West Sendromu. I.ennox-Geslaut Sendromıı ve çocukluk çağı myoklonik epilepsisi gibi epileptik sendromlann tedavisi sorun oluşturmaktadır. Hu amaçla kullanılan araştırma safhasındaki ilaçların yanışını, klinik uygulamaya sunulan dört ilaç genel bir kabul görmüştür. Santral sinir sistemindeki nörotransmitterler yolu ile etki gösteren Telbamate. Gabapentin. ; iinıııirıgıne ve l'igabatrin ile ilgili olarak yapılan klinik çalışmalarda, hastaların %20-60'ında nöbet \ı*,ıguıJii %50'ıkn luJa azalma gösterilirken. %~~ vakada nöbetleri tamamen önledikleri gösterilmiştir. Hu iiirııı ortak hır dezavantajları maliyetlerinin yüksek oluşlarıdır./Turgut Özal Tıp Merkezi Dergisi 2(1): 114-119.1995/
114-119

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