Buradasınız

Anasayfa » Content

Multinucleated giant cell on FNAC of breast lesion: A not very uncommon occurrence with varied pathology

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2014

Key Words:

Author Name
Abstract (2. Language): 
Introduction: It is well-recognized that cells of the monocyte/macrophage lineage are capable of fusion to form multinucleated giant cells (MGCs). The presence of multinucleated giant cells on FNAC smears of breast lumps have been described only sporadically in the literature. As this is a common specimen in Cytopathology, knowledge of frequency of this variation can be valuable to cytopathologist who identifies the variation and clinician who is involved with the treatment modalities of different breast pathologies. Material and Methods: The present retrospective as well as prospective study was conducted at the department of Pathology. The smears prepared were both wet and dry fixed and were subsequently stained with May Grunwald Giemsa (MGG) as well as Haematoxylin & Eosin (H& E) stain. The stained smears were observed under microscope by at least two expert cytopathologists. Orell was followed for categorizing different breast lesions and the findings were correlated with histopathology wherever available . Results: Multinucleated giant cells found were foreign body type, Langhan’s type, multinucleated stromal giant cells ( MSGC), osteoclast like giant cell and tumour giant cells. Foreign body type giant cells were found in 7 out of 23 cases. Fibroepithelial lesion namely fibroadenoma showed multinucleated stromal giant cells in 5 out of 52 cases while no giant cells were seen in cases of Phyllodes tumour. Langhan’s giant cells, tumour giant cells and osteoclastic giant were seen in 2,3 and 1 cases of tubercular mastitis, duct carcinoma, duct carcinoma with osteoclastic giant cells respectively. Conclusion: Presence of multinucleated giant cells on breast FNA smears, though not so common occurrence, demands recognition as well as correct interpretation to provide an accurate diagnoses to the surgeon. Cytomorphology of various multinucleated giant cells along with ductal epithelial cells help cytopathologists to reach at the correct diagnoses especially in cases of malignancy where various types of giant cells like benign multinucleated giant cells, osteoclast-like giant cells or tumour giant cells are encountered
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-multinucleated-giant-cell-fnac-breast-lesion-not-very-uncommon-occurrence-varied-pathology.pdf
  • 1
416
424
  • Turkish

REFERENCES

References: 

1. Brodbeck W G, Anderson J M. Giant cell formation and function. Curr Opin Hematol 2009; 16(1): 53–57.
2. Ng WK: Fine needle aspiration cytology of fibroadenoma with multinucleated stromal giant cells. A review
of cases in a six-year period. Acta cytologica 2002; 46(3):535-539.
3. Cai N, Koizumi J, Vazquez M. Mammary Carcinoma with Osteoclast-Like Giant Cells: A study of four
cases and a review of the literature. Diagnostic Cytopathology 2005; 33(4):246-251.
4. Kobayashi TK, Sugihara H, Kato M, Watanabe S. Cytologic features of granulomatous mastitis: report of a
case with fine needle aspiration cytology and immunochemical findings. Acta cytologica 1998; 42:716-720.
5. Orell SR, Grogory FS, Walters MNI, Whitaker D: Manual and Atlas of Fine Needle Aspiration Cytology. 3rd
edition. Churchill Livingstone. 2001
6. Treves N, Sunderland DA. Cystosarcoma Phyllodes of the beast; a malignant and a benign tumour. A
clinicopathological study of seventy seven cases. Cancer 1951; 4:1286-1332.
7. Rosen P. Multinucleated mammary stromal giant cells – A benign lesion that simulates invasive carcinoma.
Cancer 1979; 44(4):1305-1308.
8. Ryska A, Reynolds C, Keeney GL. Benign tumors of the breast with multinucleated stromal giant cells.
Immunohistochemical analysis of six cases and review of the literature. Virchows Arch 2001; 439:768-775.
9. Kollur S M, Hag IAE. FNA of breast fibroadenoma: observer variability and review of cytomorphology with
cytohistological correlation. Cytopathology 2006; 17(5): 239–244,.
10. Huo L, Gilcrease MZ. Fibroepithelial lesions of breastwith pleomorphic giant cells: a clinicopathologic
study of four cases and review of literature. Ann Diagn Pathol 2009; 13(4):226-232.
11. Powell C M, Cranor M L, and. Rosen P P. Multinucleated stromal giant cells in mammary fibroepithelial
neoplasms: a study of 11 patients. Archives of Pathology and Laboratory Medicine 1994; 118(9):912–916.
12. Tse G, Law BK, Chan KF, Mas TK: Multinucleated stromal giant cells in mammary phyllodes tumours.
Pathology 2001; 33(2):153-156.
13. Coyne JD, Parkinson D, Baildam AD. Membranous fat necrosis of the breast. Histopathology 1996;
28(1):24-27.
14. Walter J B, Talbot I C, Gardner H A, Halloran P F, Zuckerman M, Bird A G. Forbes A. Walter and Israel
General Pathology. Churchill Livingstone publishing 2011.7th ed; ch 11: p 198.
423
Indian Journal of Basic and Applied Medical Research; December 2014: Vol.-4, Issue- 1, P. 416-424
417
www.ijbamr.com P ISSN: 2250-284X , E ISSN : 2250-2858
15. Chandanwale S, Rajpal M, Pradeep J,Sood S,Gupta K,Gupta N. Pattern of Benign Lesions on FNAC in
consecutive 100 cases: A study at tertiary care hospital in India. IJPBS 2013; 3(4):129-138.
16. Nayar M, Saxena HMK. Tuberculosis of the breast. A cytomorphological study of needle aspirates and
nipple discharges. Acta Cytol 1984;2 8:325-328.
17. Cai N, Koizumi J, Vazquez M. Mammary Carcinoma With Osteoclast-Like Giant Cells: A Study of Four
Cases and a Review of Literature. Diagnostic Cytopathology 2005; 33:246–251.
18. Rosen PP, Hoda S, Dershaw D, Liberman Leditors. Breast Pathology: Diagnosis by Needle Core Biopsy. 2nd
ed. Lippincott: Wiliams & Wilkins; 2005.
19. Takahashi T, Moriki T, Hiroi M, Nakayama H. Invasive lobular carcinoma of the breast with osteoclast-like
giant cells: a case report. Acta Cytol 1998;42:734–741.
20. Gjerdrum L, Lauridsen MC, Sørensen FB: Breast carcinoma with osteoclast-like giant cells: morphological
and ultrastructural studies of a case with review of the literature. The Breast 2001; 10(3):231-236.
21. Kurokawa K, Mouri Y, Asano A, Kamei K, Iwata Y, Isogai M et al. Pleomorphic carcinoma with
osteoclastic giant cells of the breast: Immunohistochemical differentiation between coexisting neoplastic and
reactive giant cells. Pathology International. 2009;59: 91–97.
22. Agnantis NT, Rosen PP: Mammary carcinoma with osteoclast-like giant cells: a study of eight cases with
follow-up data. American Journal of Clinical Pathology 1979; 72:383-389.
23. Berean K, Tron VA, Churg A, Clement PB: Mammary fibroadenoma with multinucleated stromal giant
cells. American Journal of Surgical Pathology 1986;10(11):823-827.
24. McMahon RF, Ahmed A, Connolly CE. Breast carcinoma with stromal multinucleated giant cells--a light
microscopic, histochemical and ultrastructural study. J Pathol.1986;150(3):175-179.
25. Mendoza P, Lacambra M, Tan P H, Tse G M. T. Fine Needle Aspiration Cytology of the Breast: The
Nonmalignant Categories. Pathology Research International 2011;2011: 547580.
26. Maygarden SJ, Novotny DB, Johnson DE, Frable WJ. Subclassification of benign breast disease by fine
needle aspiration cytology. Comparison of cytologic and histologic findings in 265 palpable breast masses.
Acta Cytol. 1994; 38(2):115-29.
27. Sudarat N, Somneuk J, Siriwan T. Accuracy of FNAC from breast masses in Thailand. AJCP 2009;10: 623-
626.
28. Shrestha A, Chalise S, Karki S, Shakya G. Fine needle aspiration cytology in a palpable
breast lesion. Journal of Pathology of Nepal 2011; 1:131-135.

Thank you for copying data from http://www.arastirmax.com