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STUDY OF THE EFFECT OF ADHATODA ZEYLANICA AND SOME RELATED SYNTHESIZED CHALCONES ON GLUCOSE DIFFUSION IN VITRO

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Diabetes mellitus is a major disease characterized by derangement in carbohydrate, fat and protein metabolism, affecting nearly 10% of the population. Several drugs such as biguanides and sulfonyl ureas are presently available to reduce hyperglycemia. These drugs have side effects and thus searching for a new class of compounds is essential. Therefore, it is prudent to look for options in herbal medicine for diabetes. Adhatoda zeylanica is popularly used for the treatment of diabetes. A review of literature reveals that a new moiety, 2’, 4-dihydroxy chalcone-4-glucoside has been identified in the flowers of the plant. The present investigation was designed to study the antihyperglycemic effect of the chalcone containing Adhatoda zeylanica flower extract. A series of chalcone derivatives were synthesized (AC1- AC11& BC1- BC6) and their anti hyperglycemic activity was evaluated. The antidiabetic effect of the newly synthesized chalcone (AC6) was higher than the plant extract.
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PDF icon arastrmx_160852_2_pp_259-263.pdf
  • 3
259-263
  • English

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