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Hipoksiye Karşı Hücresel Cevabın Düzenleyicisi: HIF-1

Regulator of Cellular Response to Hypoxia

Journal Name:

  • Smyrna Tıp Dergisi

Publication Year:

  • 2016

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Oxygen is an essential nutrient that serves as a key substrate in cellular metabolism and bioenergetics. O2 deprivation creates stress in living cells. During low O2 (hypoxic) conditions, cells activate a number of adaptive responses. The events are coordinated by various cellular pathways including mTOR signaling, and regulation of several genes by hypoxia inducible factor (HIF). HIFs direct critical adaptations to enable cells, tissues, and organisms to survive and thrive in these conditions. Heterodimeric transcription factor hypoxia inducible factor-1 (HIF-1) functions as a master regulator of oxygen homeostasis in almost all nucleated mammalian cells, regulating the expression of a myriad of genes.
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Abstract (Original Language): 
Oksijen hücresel metabolizma ve bioenerjetik olaylarda önemli bir substrattır. Oksijen yetersizliği canlı hücrelerde strese yol açar. Düşük oksijen seviyelerinde yani hipoksik koşullarda hücreler bir seri adaptif cevap geliştirirler. Bu durum mTOR sinyal yolağı ve hipoksi ile indüklenen faktör (HIF) tarafından regüle edilen birçok gen tarafından koordine edilir. HIF proteinleri bu durumu atlatmak ve hayatta kalabilmek için hücrelerde, dokularda ve organizma boyutunda kritik adaptasyonları yönetmektedirler. Heterodimerik yapıya sahip hipoksiyle indüklenen faktör-1 (HIF-1) nükleusa sahip memeli hücrelerinde temel transkripsiyon faktörü olarak çok sayıda genin ekspresyonunu düzenlemektedir.
FULL TEXT (PDF): 
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REFERENCES

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