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BENZOİK ASİTE MARUZ BIRAKILAN CAENORHABDİTİS ELEGANS’ LARDA YAŞAM SÜRESİ ANALİZİ VE FİZYOLOJİK DEĞİŞİKLİKLER

PHYSIOLOGICAL AND LIFESPAN ALTERATIONS IN CAENORHABDITIS ELEGANS EXPOSED TO BENZOIC ACID

Journal Name:

  • Uluslararası Hakemli Akademik Spor Sağlık ve Tıp Bilimleri Dergisi

Publication Year:

  • 2013

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Benzoic acid derivatives are widely used as industrial chemicals, agrochemicals, pharmaceuticals and consumer products. Even though benzoic acid is generally considered as safe, adverse effects such as asthma, urticaria, metabolic acidosis and convulsions were observed at low doses in sensitive persons. The objective of this experimental study was to evaluate the physiological and lifespan alterations effects of different levels of benzoic acid on model animal Caenorhabditis elegans. The findings were compared with the control group. The results showed that benzoic acid fractions ( 0.1 gr, 0.06 gr, 0.02 gr / 10 ml,) had adverse effects on lifespan fertility and growing properties of Caenorhabditis elegans. On the other hand, there were not any differences between control group level and 0.008 gr, 0.001 gr / 10 ml fractions of benzoic acid in terms of lifespan effect. However, the 0.008 gr, 0.001 gr / 10 ml groups showed much lower fertility and growing properties than control group under experimental conditions of this study. In conclusion, dietary benzoic acid affects lifespan and fertility of Caenorhabditis elegans in a dose dependent manner. Therefore, it is important to assess the influence of dietary benzoic acid addition in products and its concentration has to be controlled.
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Abstract (Original Language): 
Benzoik asit ve benzoik asitten üretilen maddeler kimya endüstrisi, tarım sektörü, ilaç endüstrisi ve bir çok tüketim ürünlerinde yaygın bir şekilde kullanılmaktadır. Benzoik asitin genellikle güvenilir olduğu düşünülmesine rağmen duyarlı kişilerde düşük dozlarda bile astım, ürtiker, metabolik asidoz ve konvülsiyonlar gibi yan etkileri olduğu görülmüştür. Bu çalışmada bir model organizma olan Caenorhabditis elegans farklı dozlarda benzoik asite maruz bırakılmış, fizyolojik ve yaşam süresi değişiklikleri incelenmiştir. Bulgular kontrol grubuyla karşılaştırılmıştır. Çalışma sonucunda benzoik asitin 0.1 gr, 0.06 gr, 0.02 gr / 10 ml dozlarında Caenorhabditis elegans’ larda yaşam süresi, fertilite ve fiziksel büyüme üzerine olumsuz etkileri olduğu görülmüştür. Diğer taraftan 0.008 gr, 0.001 gr / 10 ml lik dozlarda yaşam süresi üzerinde kontrol grubuyla herhangi bir fark görülmemiştir. Fakat 0.008 gr, 0.001 gr / 10 ml dozlar fertilite ve fiziksel büyümenin kontrol grubuna gore daha az olduğu tespit edilmiştir. Sonuç olarak benzoik asitin doza bağlı olarak yaşam süresi, fertilite ve fiziksel büyüme üzerine olumsuz etkileri olduğu görülmüştür. Bu yüzden gıda ek maddesi olarak yaygın bir şekilde kullanılan benzoik asitin konsantrasyonunun kontrolü büyük önem taşımaktadır.
FULL TEXT (PDF): 
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  • 7
39-47
  • Turkish

REFERENCES

References: 

BURCU, C.O., GOKHAN, D., BURCAK,
C., (2009). Turkish preschool staff’s
opinions about hormones, additives
and genetically modified foods. Procedia
Soc Behav Sci, 1, 1734–1743.
CHUANG, M.H., CHIOU, S.H., HUANG,
C.H., YANG, W.B., WONG, C.H.,
(2009). The lifespan-promoting effect
of acetic acid and Reishi polysaccharide.
Bioorg Med Chem, 17, 7831–7840.
CHUANG, M.H., CHIOU, S.H., HUANG,
C.H., YANG, W.B., WONG, C.H.,
(2009). The lifespan-promoting effect
of acetic acid and Reishi polysaccharide.
Bioorg Med Chem, 17, 7831–7840.
FRIED, E.J., NESTLE, M., (2002). The
growing Political Movement against
46
ULUSLARARASI HAKEMLİ AKADEMİK SPOR SAĞLIK ve TIP BİLİMLERİ DERGİSİ
Nisan-Mayıs-Haziran 2013 Sayı: 07 Cilt: 3 Spring Apri -May-June 2013 Volume:03 Issue:07 Jel:I 10
www.sstbdergisi.com
ID:49 K:74
Soft Drinks in Schools. J Am Med Assoc,
288, 2181.
FRIEDMAN, M., HENIKA, P.R., MANDRELL,
R.E., (2003). Antibacterial
activities of phenolic benzaldehydes
and benzoic acids against Campylobacter
jejuni, Escherichia coli, Listeria
monocytogenes, and Salmonella enterica.
J Food Protect, 66, 1811–1821.
HAMZAH, H.H., YUSOF, N.A., SALLEH,
A.B., ABU BAKAR, F., (2011). An optical
test strip for the detection of benzoic
acid in food. Sensors, 11, 7302-
7313.
KOELLE, M.,(2005). Quantitation of constitutive
egg-laying Yale University,
New Haven,CT.USA,http://www.
wormbook.org/chapters/www_behavior/
behavior.html#sec9
LEUNG, C.K.M., WILLIAMS, P.L.,
BENEDETTO, A., CATHERINE,
A.U., HELMCKE, K.J., ASCHNER,
M., MEYER, J.N., (2008). Caenorhabditis
elegans: an emerging model in
biomedical and environmental toxicology.
Toxicol Sci, 106, 5–28.
MPOUNTOUKAS, P., VANTARAKIS, A.,
SIVRIDIS, E., LIALIARIS, T., (2008).
Cytogenetic study in cultured human
lymphocytes treated with three commonly
used preservatives. Food Chem
Toxicol, 46, pp. 2390–2393.
PAPADOMICHELAKIS, G., MOUNTZOURIS,
K.C., ZOIDIS, E.,
FEGEROS, K., (2011). Influence of
dietary benzoic acid addition on nutrient
digestibility and selected biochemical
parameters in fattening rabbits.
Anim Feed Sci Tech, 163, 207–213.
PING, G.I., HONG, H., XIAOYAN, L.,
LIU, D., (2009). Assessment of benzoic
acid levels in milk in China. Food
Control, 20, 414–418.
RAJINI, P.S., MELSTROM, P., WILLIAMS,
P.L., (2008). A comparative
study on the relationship between
various toxicological endpoints in
Caenorhabditis elegans exposed
to organophosphorus insecticides.
J Toxicol Environ Health, Part B. 71,
1043–1050.
SASAKI, Y.F., KAWAGUCHI, S., KAMAYA,
A., OHSHITA, M., KABASAWA,
K., IWAMA, K., TANIGUCHI, K.,
TSUDA, S., (2002). The comet assay
with 8 mouse organs: results with 39
currently used food additives. Mutation
Research, 519, 103–119.
SHAN, D., SHI, Q., ZHU, D., XUEA, H.,
(2009). Inhibitive detection of benzoic
acid using a novel phenols biosensor
based on polyaniline–polyacrylonitrile
composite matrix. Talanta, 72,
1767–1772.
SUTPHIN, G.L., KAEBERLEIN, M.,
(2009). Measuring Caenorhabditis elegans
life span on solid media, JJoVE,
27. http://www.jove.com/index/details.
stp?id=1152, doi: 10.3791/1152.
47
ULUSLARARASI HAKEMLİ AKADEMİK SPOR SAĞLIK ve TIP BİLİMLERİ DERGİSİ
Nisan-Mayıs-Haziran 2013 Sayı: 07 Cilt: 3 Spring Apri -May-June 2013 Volume:03 Issue:07 Jel:I 10
www.sstbdergisi.com
ID:49 K:74
TFOUNI, S.A.V., TOLEDO, M.C.F.,
(2002). Determination of benzoic and
sorbic acids in Brazilian food. Food
Control, 13, 117–123.
WEGRZYN, A.N., WALKER, M.K.C.,
WOOD, R.A., (2001). Food-Allergic
Reactions in Schools and Preschools.
Arch Pediatr Adolesc Med, 155, 790-795.
WHO.,(1997). Evaluation of some food
additives and contaminants. Technical
Report Series, 868.
WILLIAMS, P.L., DUSENBERY, D.B.,
(1990). A promising indicator of neurobehavioral
toxicity using the nematode
Caenorhabditis elegans and
computer tracking. Toxicol Ind Health,
6, 425–440.
YILMAZ, S., ÜNAL, F., YÜZBAŞIOĞLU,
D., (2009). The in vitro genotoxicity
of benzoic acid in human peripheral
blood lymphocytes. Cytotechnology,
60, 55–61.

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