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Obezite hirsutizmli kadınlarda hirsutizmin şiddetini artırır

Obesity increases the severity of hirsutism in hirsute women

Journal Name:

  • Türkiye Aile Hekimliği Dergisi

Publication Year:

  • 2012

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: Obesity was associated with various dermatologic diseases like acanthosis nigricans, acrochordons, keratosis pilaris, striae disten-sae, adiposis dolorosa, lymphedema, chronic venous insufficieny, plantar hyperkeratosis, cellulitis, various skin infections, hydradenitis supurativa, psoriasis, insulin resistance syndrome and may cause sig¬nificant changes in endocrine parameters. Hyperandrogenism and hir-sutism are the most important ones among them. However relation¬ship between obesity and hirsutism severity has not been document¬ed well in literature despite the fact that relationship between obesity and hirsutism is known well. The aim of this study is to investigate the relationship between obesity and hirsutism severity in obese and non-obese hirsute women. Methods: A total of 38 obese (18 hyperandrogenemic, 20 nor-moandrogenemic) and 38 non-obese (18 hyperandrogenemic, 20 normoandrogenemic) premenopausal hirsute women who were matched according to age were included in the study. Patients underwent an appropriate endocrinologic analysis for this pur¬pose. Hirsutism was defined as Ferriman-Gallwey (FG) score >8. Obesity was defined as BMI>27 kg/m2. Results: Hirsutism score was significantly higher in obese women compared to non-obese women (p<0.05). Severity of hirsutism was significantly higher in obese women compared to non-obese (p<0.001). There was not a significant difference between hyper-androgenemic and normoandrogenemic obese and non-obese women in terms of hirsutism severity (p>0.05). Conclusions: Obesity increases hirsutism severity.
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Abstract (Original Language): 
Amaç: Obezite, akantozis nigrikans, akrokordonlar, keratozispila-ris, striae distensae, adipozis dolorosa, lenfödem, kronik venöz yetmezlik, plantar hiperkeratoz, selülit, çeşitli deri enfeksiyonları, hidradenitis süpürativa, psoriasis, insulin rezistans sendromu gibi çeşitli dermatolojik hastalıklarla ilişkilendirilmiştir ve endokrin parametrelerde önemli değişikliklere neden olabilmektedir. Bunlar arasında hiperandrojenizm ve hirsutizm en önemlileridir. Ancak obezite ve hirsutizm arasındaki ilişki iyi bilinmesine rağmen, obezite ile hirsutizm şiddeti arasındaki bu ilişki literatürde, iyi bir şekilde dökümante edilmemiştir. Bu çalışmanın amacı obez ve obez olmayan hirsutizmli kadınlarda, obezitenin hirsutizm şiddetiyle ilişkisini araştırmaktır. Yöntem: Çalışmaya yaşa göre eşleştirilmiş 38 obez (18'i hiperan-drojenemik, 20'si normoandrojenemik) ve 38 obez olmayan (18'i hiperandrogenemik, 20'si normoandrojenemik) premenapozal hir-şut kadın dahil edildi. Bunun için hastalar uygun bir endokrinolojik araştırmaya tabi tutuldu. Hirsutizm tanısı Ferriman-Gallwey (FG) skoru >8 olarak tanımlandı. Obezite vücut kitle indeksi (VKİ) >27 kg/m2 olacak şekilde tanımlandı. Bulgular: Obez kadınlarda hirsutizmin şiddeti obez olmayan kadınlardan anlamlı derecede daha yüksekti (p<0.001). Hiperandro-jenemik ve normoandrojenemik obez olan ve obez olmayan ka¬dınlar arasında hirsutizmin şiddeti açısından istatistiksel olarak anlamlı bir fark yoktu (p>0.05). Sonuç: Obezite hirsutizmin şiddetini artırır.
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  • 3
119-122
  • Turkish

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