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IgA Nefropatili Çocukların Oxford Sınıflamasına Göre Değerlendirilmesi

Evaluation of Children with IgA Nephropathy According to the Oxford Classification

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2013
DOI: 
DOI 10.5262/tndt.2013.1001.04

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
OBJECTIVE: In this study, we aim to evaluate the clinical findings and short term results of our patients with IgAN according to Oxford classification. MA TERIAL and M ETHODS: The medical records and the renal biopsy findings of 25 patients with IgAN were retrospectively reviewed. According to the pathological findings in Oxford classification, those without obvious disorder were accepted as Group 1 (n=16), and those with obvious disorders were accepted as Group 2 (n=9).These groups were compared for gender, age of onset, age of diagnosis, mean blood pressure and estimated glomerular filtration rate (GFR) at diagnosis and follow-up, proteinuria, clinical presentation and prognosis. RESUL TS: The most common complaint of the patients at presentation was hematuria. The most common histopathological renal finding was the proliferation of mesengial cells in varying degrees. Statistically no significant differences of mean blood pressure, GRF changes, protenuria, clinical findings, and prognosis were detected at presentation and follow-up. CONCLU SION: We could not show short-term effectiveness to predict clinical and laboratory findings, and prognosis of the patients of Oxford classification in children with IgAN.
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Abstract (Original Language): 
AMA Ç: Bu çalışmamızda, IgA nefropatisi (IgAN) ile izlenen çocuklarda Oxford Sınıflaması kullanılarak hastaların klinik bulguları ve kısa dönem sonuçlarının değerlendirilmesi amaçlanmıştır. GEREÇ ve YÖN TEML ER: Kliniğimizde izlenen 25 IgAN’li olgunun dosya kayıtları ve böbrek biyopsi bulguları geriye dönük olarak değerlendirildi. Oxford Sınıflamasındaki patolojik bulgulara göre aşikar bozukluğu olmayanlar Grup 1 (n=16) ve olanlar Grup 2 (n=9) olarak kabul edildi. Gruplar cinsiyet, tanı yaşı, belirti, başlangıç yaşı, başvuru ve takipte ortalama kan basıncı düzeyleri, glomerüler filtrasyon hızı (GFR) değişiklikleri, proteinüri, klinik bulgular ve prognoz açısından karşılaştırıldı. BUL GULA R: Hastaların en yaygın başvuru yakınması makroskopik hematüri idi. En yaygın görülen böbrek histopatolojik bulgusu değişik derecelerde mezengial hücre artışı idi. Başvuru ve takipte ortalama kan basıncı düzeyleri, GFR değişiklikleri, proteinüri, klinik bulgular ve prognoz açısından anlamlı farklılık saptanmadı. SONU Ç: Bu çalışmada, IgAN’li çocuklarda Oxford Sınıflamasının klinik ve laboratuvar bulguları ve prognozu göstermede kısa dönem etkinliği gösterilememiştir.
FULL TEXT (PDF): 
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  • 1
30-33
  • Turkish

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