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Üremik Kaşıntı

Uremic Pruritus: Still Itching

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DOI: 
DOI 10.5262/tndt.2011.1001.02

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Abstract (2. Language): 
Uremic pruritus is a common complication of chronic renal failure. It affects 50% of patients undergoing hemodialysis or peritoneal dialysis. The causes of pruritus in uremic patients are still unknown. Xerosis, intradermal microprecipitation of divalent ions, secondary hyperparathyroidism, peripheral neuropathy, allergic reactions, hypersensitivity and histamine have been considered as pathogenetic factors. The cornerstone of therapy for uremic pruritus is regular, intensive, efficient dialysis. Other therapeutic measures include topical emollients, topical capsaicin, systemic antihistaminics, gabapentine and phototherapy.
Abstract (Original Language): 
Üremik kaşıntı kronik böbrek yetmezliği hastalarında sık görülen komplikasyonlardan biridir. Hemodiyaliz ya da periton diyalizi programındaki hastaların yaklaşık %50’sinde görülmektedir. Üremik kaşıntının nedeni hala net olarak bilinmemektedir. Cilt kuruluğu, iki değerlikli iyonların ciltte presipitasyonu, ikincil hiperparatiroidi, periferik nöropati, allerjik reaksiyonlar, hipersensitivite ve histamin üremik kaşıntıdan sorumlu tutulan nedenlerdir. Üremik kaşıntıda en önemli tedavi basamağı düzenli, yoğun ve etkili diyaliz yapmaktır. Topikal nemlendiriciler, topikal capsaicin, sistemik antihistaminikler, gabapentin ve fototerapinin üremik kaşıntı tedavisinde yeri bulunmaktadır.
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