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RANİTİDİN BİZMUT SİTRAT VE KLARİTROMİSİNLİ İKİLİ KOMBİNASYONLA ALTERNATİF HELİKOBAKTER PYLORİ TEDAVİSİ

RANITIDINE-BISMUTH CITRATE AND CLARITROMYCIN DOUBLE THERAPY AS ALTERNATIVE STRATEGY FOR HELICOBACTER PYLORI TREATMENT

Journal Name:

  • İstanbul Tıp Fakültesi Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Objective: To evaluate the efficacy of a strategy combining ranitidine-bismuth citrate (RBS) and clarithromycin double therapy for Helicobacter pylori (Hp) eradication with dudenal ulcer and/or gastrit 44 patients. Materials and methods: Forty four consecutive Hp-positive patients, with duodenal ulcer and/or gastrit were treated with 400 mg ranitidine-bismuth citrate twice daily for 30 days, 500 mg clarithromycin twice daily for 14 days between April 1998-May 1999. The efficacy of the treatment was evaluated by histology a month after treatment. Results: Forty four patients were 15 male, 29 female (mean age 45.93±14.03, range 17-85). Epigastric pain (100%), pyrozis, abdominal distension were common symptomes. This symptomes had regressed after treatment. Cure rates were 12/13 (92.3%) duodenal ulcer and 37/44 Hp-positive patients (84.09%). Conclus›ons: RBS and clarithromycin combination achieve good eradication rates (84.09%). As the first-line therapy avoids the use of RBS and clarithromycin combination, it could be useful in areas where high resistance lead to poor results with triple therapy.
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Abstract (Original Language): 
Amaç: Endoskopik incelemesinde Helikobakter pylori (Hp) enfeksiyonunun efllik etti¤i duodenal ülser ve/veya gastrit tesbit edilen 44 hastada Ranitidin bizmut sitrat (RBS) ve Klaritromisin kombinasyonunun tedavide etkinli- ¤ini araflt›rmak. Gereç ve yöntem:Nisan 1998, May›s 1999 tarihleri aras›nda gastroskopilerinde Hp enfeksiyonunun efllik etti¤i duodenal ülser ve/veya gastrit tesbit edilen, çal›flmaya al›nmay› kabul eden, ard›fl›k 44 hasta prospektif olarak çal›flmaya al›nd›. Hastalara 30 gün süreyle RBS 400 mg 2x1, 14 gün süreyle klaritromisin 500 mg 2x1 verildi, tedavi bitiminden 1 ay sonra kontrol endoskopik incelemeleri yap›ld›. Bulgular: 44 hastan›n 15’i erkek, 29’u kad›n; yafl ortalamas› 45,93±14,03 da¤›l›m› 17-85 idi. En s›k gözlenen semptomlar epigastrik a¤r› (%100), pirozis ve fliflkinlik idi. Tedavi sonras› hastalar›n flikayetlerinde belirgin gerileme gözlendi. Onüç duodenal ülserli hastadan 12’si iyileflti (% 92,3) ve 44 hastadan 37’sinde (% 84,09) Hp eradikasyonu sa¤land›. Sonuç: RBS ve klaritromisin kombinasyonuyla %84,09 oran›nda Hp eradikasyonu sa¤lanm›fl olup bu kombinasyonun klasik üçlü eradikasyon tedavisine özellikle dirençli bölgelerde alternatif olabilece¤i düflünüldü.
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  • 3
61-64
  • Turkish

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