Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
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Abstract (2. Language):
Gel formulation provides better application property and stability in comparison to cream
and ointment. Topical gel drug administration is a localized drug delivery system anywhere in the body
through ophthalmic, rectal, vaginal and skin as topical routes. Skin is one of the most extensive and
readily accessible organs on human body for topical administration and is main route of topical drug
delivery system. Topical application of drugs offers potential advantages of delivering the drug directly
to the site of action and acting for an extended period of time. Topical gels are intended for skin
application or to certain mucosal surfaces for local action or percutaneous penetration of medicament
or for their emollient or protective action.1 Gels are defined as semi-rigid systems in which the
movement of the dispersing medium is restricted by an interlacing three-dimensional network of
particles or solvated macro-molecules in the dispersed phase. Physical and /or chemical cross-linking
may be involved. The interlacing and consequential internal friction is responsible for increased
viscosity and the semisolid state. Gels are evaluated by following parameters such as pH, homogeneity,
grittiness drug content, viscosity, spreadability, extrudability, skin irritation studies, in vitro release, in
Stability.
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FULL TEXT (PDF):
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