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FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF METOPROLOL TARTRATE

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
The objective of present investigation was to prepare and evaluate a pulsatile drugdelivery system of metoprolol tartrate. The prepared pulsatile delivery system consists of two different parts: a core tablet, containing the active ingredient, an erodible . The rapid release core tablet (RRCT) was prepared by using superdisintegrants along with active ingredient metoprolol tartrate. press coating of optimized RRCT was done by using different ratios of hydroxy propyl methyl cellulose (HPMC K100) and ethyl cellulose 5Cps. Developed formulations were evaluated for their physical characteristics, in vitro disintegration time and in vitro drug release profile (lag time).On the basis of these evaluation parameters it was found that optimized pulsatile release formulation (P3F3) showed time of 2hrs and in-vitro drug relrease time of 8hrs with97.8%released drug. The P3F3 formulation showed compliance with chronotherapeutic objective of hypertension.
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Research Article CODEN: IJPRNK ISSN: 2277-8713
K. Surendra Kumar, IJPRBS, 2013; Volume 2(5):246-257 IJPRBS
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