Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
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Abstract (2. Language):
The aim of present study was to develop a new colon targeting formulation, which can
minimize the escape of Mesalazine completely in upper gastro
ensure availability of maximum amount of drug to achieve the desired site i.e. distal
colon. The use of press coated tablets with Hydroxypropylmethylcellulose acetate
succinate (HPMCAS) and sodium alginate in outer shell was investigated. Two coats
(upper and lower) were compressed onto the core tablets of Mesalazine using varying
quantities of coating composition i.e. 100mg and 150mg each for lower and upper coat.
The Mesalazine tablets coated by compressing 100 mg of HPMCAS each as upper and
lower coat did not maintain integrity of the coats and released almost 100% of drug
within 3 hrs. The tablets coated by compressing 150 mg of HPMCAS on the core tablets
maintained good integrity during the dissolution test and prevented escape of
Mesalazine totally in acid stage and buffer sage 1. However, the release of Mesalazine
in subsequent buffer stage 2 was also affected.
blends of HPMCAS and sodium alginate could maintain good mechanical strength in
acid stage and buffer stage 1 and released 81.65 % of drug within 5 hrs. While the
tablets with higher proportion of Sodium alginate in coat although possessed good
mechanical strength indicated slower release of drug. The amount of Mesalazine
released from the tablets coated with higher proportion of HPMCAS alone was
comparable to that released from the tablets coated w
sensitive polymers. These release indicating the usefulness of press coated tablets.
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