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ANTIMICROBIAL SUSCEPTIBILITY OF METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS TO VARIOUS ANTIBIOTICS WITH SPECIAL REFERENCE TO PRISTINAMYCIN

Journal Name:

  • The International Journal of Pharmaceutical Research and Bio-Science

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Methicillin-resistant Staphylococcus aureus (MRSA) is a major nosocomial pathogen worldwide. Vancomycin is the traditional drug of choice, but decreasing susceptibility to vancomycin and other glycopeptides has been reported since 1996. The present study was carried out to test the in vitro activity of other antimicrobial agents with special reference to pristinamycinagainst MRSA isolates recovered from hospitalized patients. We tested 100 MRSA isolates recovered from hospitalized patients. Staphylococcus aureus was identified by Gram's staining, catalase and coagulase test; followed by cefoxitin test for identifying MRSA. Susceptibility to other antibiotics was tested by the disk diffusion method. Antibiogram to MRSA isolates shows high resistance to Erythromycin (89%) and low resistance to Chloramphenicol (11%) and for the remaining antibiotics the resistance frequencies were: Pristinamycin (79%), Cotrimoxazole (67%) Gentamicin (57%), Tetracycline (34%), Clindamycin (31%) and Chloramphenicol (11%). The alarmingly increasing trend of MRSA infection calls for the implementation of an effective infections control policy which helps in counter acting the bioterror, if not completely eradicating it. Minimizing the antibiotic pressure is essential to control the emergence of resistance strains in the hospital and in the community.
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  • 5
351-358
  • English

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