DEVELOPMENT AND EVALUATION OF VARIOUS ORAL HERBAL FORMULATIONS FOR ANTI-ASTHMATIC PLANT EXTRACT

To develop and evaluate herbal oral dosage forms (Conventional Tablet and Syrup) for ease of dispensing and consumption of dry powder of ethanolic extract of leaves « of Hiptage benghalensis (L) Kurzz used to treat asthma and to check pharmacological effect of formulated dosage form by suitable experimental animal model. Tablet form was developed by wet granulation and direct compression methods to determine the more suitable method using various excipients like MCC, Lactose etc. By considering difficulty of solubility of herbal drugs in a vehicle, in one of the liquid class, decoction form of drugs in specific vehicle was used. Formulated dosage forms then subjected to evaluation of production quality by different methods stated as per official compendia. the evaluated formulation were than subjected to check for its efficacy by using experimental animal model like histamine and Ach induced bronchoconstriction in guinea pigs. Such evaluation has unique position in development of new herbal formulations. The prepared tablets were spherical puffy green colour with smooth surface having acceptable elegance. W5 form of tablets was of good quality with regard to hardness, friability & weight variation. W5 form of the tablets formulated with starch paste (6% w/v) as disintegrating agent & binder show disintegration within 549±0.57 second. The liquid oral herbal dosage forms like liquid oral prepared showed good elegance. The liquid oral evaluated for measurement of pH, specific gravity & stability. The final formulation found to have pH 6.94±0.023 and specific gravity 1.34±0.045 gm/ml. The results of stability study of final liquid oral form of drugs indicate the homogeneity of syrup without turbidity at storage temperature. Formulated dosage forms significant protection from histamine and Ach induced brocnchospasm when compared to control group and is comparable to crude extract of Hiptage benghalensis and marketed anti-asthmatic product.