You are here

HEPATITIS B AND C VIRAL INFECTIONS AMONG BLOOD DONORS AT BAHIR DAR, ETHIOPIA

Journal Name:

Publication Year:

DOI: 
10.5958/j.2319-5886.2.3.110
Abstract (2. Language): 
Background: Hepatitis B virus and hepatitis C virus are the major public health problem world wide that affects billions of people. In the study area, there is lack of available information on this issue. Aims: the aim of the study was to assess seroprevalence of HBV and HCV among blood donors. Method: A cross sectional study was conducted among blood donors attending Bahir Dar Felege Hiwot Referral Hospital. Five milliliters of blood samples were collected and screened with ELISA tests for detecting hepatitis B surface antigen and anti hepatitis C virus antibody. Chi-squared and fisher exact tests were used for the analytical assessment. Results: Out of 2384 blood donors examined, 108(4.5%) were seropositive for at least one of the two Hepatitis diseases markers of which five were co-infected. The prevalence of HBs Ag and anti-HVC was 4.11% and 0.63%, respectively. High seropositivity of HBV (8.3%) was noticed among >45 years old and HBV positivity were significantly higher among males (4.4%) than females (1.45%) (P =0.04). HCV prevalence was significantly higher in >45 years old (2.5%, p=0.01). Conclusion: The prevalence of HBV and HCV were high and the diseases were still major health problem in elderly people in the study area, which alerts public health intervention as soon as possible.
FULL TEXT (PDF): 
624- 630

REFERENCES

References: 

1. Schmidt M, Nübling CM, Scheiblauer H,
Chudy M, Walch LA, Seifried E et al. The
anti-HBc screening of blood donors: a
comparison of nine anti-HBc tests. Vox
Sanguinis. 2006; 91:237–43.
2. Lok AS. Chronic hepatitis B. N Eng J Med.
2002; 346:1682–3.
3. Darwish MA, Raouf TA, Rushdy P,
Constantine NT, Rao MR, Edelman R. Risk
factors associated with a high seroprevalence
of hepatitis C virus infection in Egyptian
blood donors. Am J Trop Med Hyg. 1993;
49:440–7.
4. Tsega E. Epidemiology, prevention and
Treatment of viral hepatitis with emphasis on
new developments. Review article. Ethiop
Med J. 2000; 38:131–41.
5. Abebe A, Nokes DJ, Dejene A, Enquselassie
F, Messele T, Cutts FT. Seroepidemiology of
hepatitis B virus in Addis Ababa, Ethiopia:
transmission patterns and vaccine control.
Epidemiol. Infect. 2003; 131:757–70.
6. Schreiber GB, Busch MP, Kleinman SH and
Korelitz JJ. The risk of transfusion
transmitted viral infections. N Engl J Med.
1996; 334:1685–90.
7. Bihl F, Castelli D, Marincola F, Dodd RY,
Brander C. Transfusion-transmitted
infections. Journal of Translational Medicine.
2007;5:25
8. UNAIDS. Report on the global AIDS
epidemic. Geneva, Joint United Nations
program on HIV/AIDS. 2002.
9. Fasola FA, Otegbayo IA. Post-transfusion
hepatitis in sickle cell anaemia; retrospectiveprospective
analysis. Nig J Clin Pract. 2002;
5:16–19.
10. Drosten C, Nippraschk T, Manegold C,
Meisel H, Brixner V, Roth WK, et al.
Prevalence of Hepatitis B virus DNA in anti-
HBC positive/H
BsAg- negative sera correlates with HCV but
not HIV serostatus. J Clin Virol. 2004;
29:59–68.
11. Gelaw B, Mengistu Y. The prevalence of
HBV, HCV and Malaria parasites among
blood donors in Amahra and Tigray regional
states. Ethiop.J.Health Dev. 2007; 22:3−7.
12. Hajrullah F, Skender T. Prevalence of HBV
and HCV among blood donors in Kosovo.
Virology Journal. 2009; 6:21.
13. El-Gilany AH, El-Fedawy S. Bloodborne
infections among student voluntary blood
donors in Mansoura University, Egypt. East
Mediterr Health J. 2006; 12:742−8.
14. Uneke CJ, Ogbu O, Inyama PU, Anyanwu
GI, Njoku MO, Idoko JH. Prevalence of
hepatitis-B surface antigen among blood
donors and human immunodeficiency virusinfected
patients in Jos, Nigeria. Mem Inst
Oswaldo Cruz, Rio de Janeiro. 2005;
100:13−16.
15. Pahuja S, Sharma M, Baitha B, Jain M.
Prevalence and trends of markers of HBV,
HCV and HIV in New Delhi blood donors a
630
Abate et al., Int J Med Res Health Sci. 2013;2(3):624-630
hospital based study. India, Jph J infec Dis.
2007; 60:389−91.
16. Afsar I, Gungor S, Sener AG, Yurtsever SG.
The prevalence of HBV, HCV and HIV
infections among blood donors in Izmir,
Turkey. Indian J Med Microbiol. 2008;
26:288−89.
17. Karaosmanoglu HK, Aydin OA, Sandikci S,
Yamanlar ER, Nazlican O. Seroprevalence of
hepatitis B: Do blood donors represent the
general population? J Infect Dev Ctries.
2012; 6:181–83.
18. Khmmaj A, Habas E, Azabi M. Frequency of
hepatitis B, C, and HIV viruses among blood
donors in Libya. Libyan J Med. 2010;
5:5333.
19. Ghavanini AA, Sabri MR. Hepatitis B
surface antigen and anti-hepatitis C
antibodies among blood donors in the Islamic
Republic of Iran. East Mediterr Health J.
200; 6:1114–16.
20. Mastouri M, Ben othman S, Bouzgarrou N,
Hassin M, Pozzetto B, Trabelsi A, et al .
Virus de l'hépatite C chez les donneurs de
sang dans la région de Monastir (Tunisie):
Prévalence et facteurs de risque. MHA. 2004;
16:59–62.
21. Etard JF, Colbachini P, Dromigny JA.
Hepatitis C antibodies among blood donors
in Senegal. Emerg Infect Dis. 2001; 9:1492–
93.
22. Alemeshet Y, Fissehaye A, Alima H.
Hepatitis B and C Viruses Infections and
Their Association With Human
Immunodeficiency Virus: A Cross-Sectional
Study Among Blood Donors In Ethiopia.
Ethiop J Health Sci. 2011; 21:67–75.
23. Viet L, Lan NTN, Ty PX, Bjorkvoll B, Hoel
H, Gutteberg T, et al. Prevalence of hepatitis
B and hepatitis C virus infections in potential
blood donors in rural Vietnam. Indian J Med
Res. 2012; 136:74–84.
24. Rahlenbeck SI, Yohannes G, Molla K,
Reifen R, Assefa A. Infection with HIV,
syphilis and hepatitis B in Ethiopia: a survey
in blood donors. Int J STD AIDS. 1997;
8:261−4.
25. Oronsaye FE, Oronsaye JI. Prevalence of
HIV-positives and hepatitis B surface
antigen-positives among donors in the
University of Benin Teaching Hospital,
Nigeria. Trop Doct. 2004; 34:159−60.

Thank you for copying data from http://www.arastirmax.com