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Diyaliz hastalarında inflamasyon nedenleri ve muhtemel tedavi seçenekleri

The causes of the inflammation and possible therapeutic options in dialysis patients

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Abstract (2. Language): 
Cardiovascular morbidity and mortality are increased in patients with chronic kidney disease and especially dialysis. In patients with uremia, inflammation starts long before renal replacement therapy. Besides the other important parameters such as malnutrition and atherosclerosis, inflammation is one of the most important causes of morbidity and mortality in uremic patients. An association between cardiovascular mortality and morbidity and inflammation in both chronic kidney disease and dialysis patients has been demonstrated by a lot of studies in the past. Inflammation in patients with renal failure who have not yet begun dialysis and in patients receiving dialysis has shown increased levels of inflammatory markers, such as Creactive protein, interleukin-6, tumor necrosis factoralpha. In this review, it is tried to discuss both possible causes of inflammation and possible therapeutic strategies in dialysis patients.
Abstract (Original Language): 
Kronik böbrek hastaları ve özellikle diyaliz hastalarında kardiyovasküler morbidite ve mortalite artmıştır. Üremili hastalarda inflamasyon, renal replasman tedavisinden uzun süre önce başlamaktadır. Malnütrisyon ve ateroskleroz gibi önemli parametrelerin yanında inflamasyon, üremik hastalardaki mortalite ve morbiditenin en önemli nedenlerinden birisidir. Kardiyovasküler mortalite ve morbidite ile inflamasyon arasındaki ilişki, hem kronik böbrek hastaları hem de diyaliz hastalarında geçmişte yapılan pek çok çalışma ile gösterilmiştir. Henüz diyalize başlamamış olanlar ve halen diyalize girmekte olan böbrek yetmezliklilerde C-reaktif protein, interlökin-6 ve tümör nekrozis faktör-alfa gibi inflamasyon belirteçlerinde artışlar gösterilmiştir. Bu derlemede diyaliz hastalarındaki inflamasyonun hem muhtemel nedenleri, hem de muhtemel tedavi stratejileri tartışılmaya çalışılmıştır.



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