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EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF BAUHINIA PURPUREA LINN

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author NameUniversity of Author
Abstract (2. Language): 
Present study was carried out to investigate different extracts of Bauhinia purpurea (B.P) for its hepatoprotective activity against CCl4 induced hepatotoxicity. The different parts of Bauhinia purpurea were collected authenticated and were subjected to extraction using solvent alcohol. Healthy wistar albino rats (150-200g) of male sex were used for the in-vivo investigations. Liver damage was induced by administration of 30% CCl4 suspended in olive oil (1ml/kg body weight). Activities of liver marker enzymes, glutamate oxaloacetate transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), acid phosphatase (AP), alkaline phosphatase (ALP), total albumin (TA), total bilirubin (TB), Total protein (TP), direct bilirubin (DB) at a dose (100mg/kg, 200mg/kg and 400 mg/kg) ethanol extract of stem, root, leaves, and flower of B.P. The results obtained shown a significant hepatoprotective effect in comparison with the standard (sylimarin). It is also confirmed by liver histopathology of treated animals. The present study demonstrated the extracts of B.P have hepatoprotective effect against CCl4 induced hepatotoxicity.
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  • 3
275-278
  • English

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