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SELF-EMULSIFYING DRUG DELIVERY SYSTEM: A REVIEW OF THEIR APPLICABILITY IN DRUG DELIVERY TECHNOLOGIES

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2014

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Abstract (2. Language): 
Around 40% of novel chemical entities show evidence of poor aqueous solubility due to their low bioavailability. Selfemulsifying drug delivery systems (SEDDS) have gain exposure to improve the bioavailability of hydrophobic drugs. SEDDSs are belongs to lipid formulations, and size range is from100nm (SEDDs) to less than 50nm (SMEDDs) and contains a isotropic mixtures of oils, surfactants, and co-surfactants, which are emulsified in aqueous media under conditions of gentle stirring. The theory behind dissolution rate improvement by means of SEDDS is the spontaneous development of the emulsion in the gastrointestinal tract with mild agitation provided by gastric mobility, which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption. Due to its small globule size, the micro/nanoemulsifed drug can easily be absorbed through lymphatic pathways, thereby bypassing the hepatic first-pass effect. This article gives in overview of SEDDS with emphasis on different types of self-emulsifying formulation, characterization, application, advantages and recent development.
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