Journal Name:
- Advance Research in Pharmaceuticals and Biologicals
Abstract (2. Language):
The anti-diabetic properties of Fenugreek (Trigonella foenum) seeds are due to 4-hydroxyisoleucine, a free amino acid.
This compound stimulates insulin secretion and this extract is formulated into microbeads and controlled release can
decrease the dosing times. This research article includes formulation and evaluation of a controlled drug delivery (CDD)
i.e., swelling controlled microbeads containing the extracts of Trigonella foenum. The in-vitro drug release study reveals
that the batch containing sodium alginate and HPMC (9:1) possesses better drug release at 7.4 pH in a sustained manner
with better entrapment efficiency, degree of swelling, physical appearance including particle size and shape
comparatively. Further pharmacological screening by Oral Glucose Tolerance Test method on animal models confirmed
the sustained drug release and anti-hyperglycaemic activity. By developing this swelling controlled drug delivery
system, a novel approach was made to prove the effect of 4-hydroxy isoleucine in Trigonella foenum seed extract as an
anti-diabetic agent and a measure to validate the traditional use of fenugreek seed in anti-diabetic treatment.
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