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SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS): A REVIEW

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2014

Key Words:

Author Name
Abstract (2. Language): 
Oral route is the most convenient route of drug administration, being non invasive, cost effective, thereby leading worldwide drug delivery market. But major problem encountered in oral formulations, is low bioavailability, giving rise to further problems like, high inter and intra subject variability, lack of dose uniformity and finally leading to therapeutic failure. For the therapeutic delivery of lipophillic drugs (BCS class II drugs), lipid based formulations are inviting increasing attention Number of technological strategies are investigated for improving bioavailability like solid dispersions, cyclodextrins, micronization etc. But Self-microemulsifying Drug Delivery System (SMEDDS) have gained exposure for their ability to increase solubility and bioavailability of poorly aqueous soluble drugs with reduction in dose and also drugs are protected from hostile environment in gut. This review gives complete overview of SMEDDS but special attention has been paid to formulation design, evaluation and little emphasis on application of SMEDDS.
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  • English

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