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Lamotrijin kullanımı ile ilişkili antikonvülzan hipersensitivite sendromu: Olgu sunumu

Anticonvulsant hipersensitivity syndrome related with the use of lamotrigine: case study

Journal Name:

  • Türkiye Aile Hekimliği Dergisi

Publication Year:

  • 2010
DOI: 
doi:10.2399/tahd.10.192

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Anticonvulsant hypersensitivity syndrome is a drug adverse reaction characterized with fever, lymphadenopathy, nephritis, conjuntivitis, and some hematologic abnormalities. Skin lesions range from morbiliform skin eruptions to toxic epidermal necrolysis. Although, this syndrome is most frequently associated with aromatic anticonvulsants, it can also be seen in association with new drugs such as lamotrigine. Herein, 68 year-age old, female, diagnosed with toxic epidermal necrolysis after lamotrigine treatment for uncontrolled epileptic seizures is represented. In her dermatologic examination, numerous bullous lesions were established with erythema on upper and lower extremities and also trunk and gluteal region. Histopathologic exami¬nation was compatible with toxic epidermal necrolysis. Patient was evaluated as anticonvulsant hypersensitivity syndrome with fever, increased liver function tests and skin eruptions. Lesions regressed in a short period of time with corticosteroid treatment. Although there is limited number of hypersensitivity cases associated with the new generation antiepileptic lamotrigine in the literature, we should remember that, it may cause the anticonvulsant hypersensitivity syndrome.
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Abstract (Original Language): 
Antikonvülzan hipersensitivite sendromu ateş, döküntü, lenfade-nopati, hepatit, nefrit, konjonktivit ve bazı hematolojik bozukluklarla karakterize bir ilaç reaksiyonudur. Deri bulguları morbiliform döküntüden toksik epidermal nekrolize kadar değişebilmektedir. Bu tablo en sık aromatik antikonvulzanlarla gelişmekle beraber, lamotrijin gibi yeni kuşak antiepileptiklerde etken olabilir. Burada, denetlenemeyen nöbetleri nedeniyle lamotrijin kullanırken toksik epidermal nekroliz gelişen 68 yaşındaki kadın hasta sunulmaktadır. Hastanın dermatolojik muayenesinde kol ve bacaklarda, gövdede ve gluteal bölgede çok sayıda eritemli bül saptandı. Histopa-tolojisi toksik epidermal nekrolizle uyumluydu. Hasta ateş, karaci¬ğer fonksiyon testleri yüksekliği ve deri bulguları ile antikonvulzan hipersensitivite sendromu olarak değerlendirildi. Kortikosteroid tedavisi ile tüm lezyonlar kısa sürede geriledi. Yeni kuşak antiepilep-tiklerden lamotrijin ile bildirilmiş toksik epidermal nekroliz olgula¬rı az sayıda olmasına rağmen bu antiepileptiğin de hipersensitivi-teye yol açabileceği unutulmalıdır.
FULL TEXT (PDF): 
PDF icon arastrmx_116859_14_pp_192-195.pdf
  • 4
192-195
  • Turkish

REFERENCES

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