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BÖBREK TRANSPLANTASYONU YAPILAN HASTALARDA SERUM SOLUBL ÎNTERLÖKÎN-2 RESEPTÖR DÜZEYİ ÖLÇÜMÜNÜN AKUT REJEKSÎYON TANISINDAKİ DEĞERİ

THE VALUE OF SERUM SOLUBLE INTERLEUKÎN-2 RECEPTOR LEVELS IN DIAGNOSIS OF ACUTE REJECTION IN RENAL TRANSPLANT RECİPLENTS

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Soluble interleukin-2 receptor (sIL-2R) levels were measured as a marker of T lymphocyte activation in serial serum samples from 15 renal transplant recipients and 15 healthy subjects. Pretransplant serum SİL-2R levels were significantly elevated above the normal controls (p< 0.0001).These values were decreased in patients with stable graft function after transplantation (p< 0.0001). In patients with acute rejection, serum sIL-2R levels were significantly higher than in those with other causes of graft dysfunction (p< 0.001) or stable graft function (p < 0.0001). The results suggest that serum SİL-2R monitoring may have a role in the early diagnosis of acute rejection.
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Abstract (Original Language): 
T lenfosit aktivasyonunun bir göstergesi olarak 15 renal transplant alıcısından ve 15 sağlıklı bireyden alınan serum örneklerinde solubl interlökin-2 reseptör (slL-2R) düzeyi ölçüldü. Pretransplant serum slL-2R düzeyleri kontrol grubundan anlamlı olarak yüksek idi(p< 0.0001 ).Bu değerler transplantasyon sonrası greftfonksiyonu stabil olan hastalarda anlamlı olarak azaldı (p < 0.0001). Akut rejeksiyonlu hasta-lardaki serum sIL-2R düzeyi diğer nedenlere bağlı greft fonksiyon bozukluğu olan hastalarda (p< 0.001) ve stabil greft fonksiyonlu hastalardan (p< 0.0001) anlamlı olarak yüksek bulundu. Bu sonuçlar, serum sIL-2R düzeyi izlenmesinin akut rejeksiyonun erken tanısında rolü olabileceğini düşündürmektedir.
FULL TEXT (PDF): 
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  • 1
21-24
  • Turkish

REFERENCES

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