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Hipokalsemiyle Seyreden Liddle Sendromu

Liddle's Syndrome With Hypocalcemia

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Liddle syndrom e is an autosomal dominant form of salt-sensitive hypertension caused by mutations İn the epithelial sodium channel expressed in the distal nephron which plays an essential role in Na' absorption. To our knowledge, this is the oldest patient with Liddle syndrome and hipocalcemia that has been reported in the literature. A 85-year-old woman with hypertension was hospitalized with somnolence and symptoms of hypocalcemia and hypokalemia. She was found to have hypokalemia, hypocalcemia, and metabolic alkalosis. Detailed examination revealed hyperkaliuria and slightly decreased plasma renin activity and plasma aldosterone concentration. The patient, diagnosed with Liddle's syndrome, was successfully treated with triamterene. In conclusion, for the patients with metabolic alkalosis, hypokalemia, hypertension and hyperkaliuria, the possibility of Liddle's sydrome must be excluded.
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Abstract (Original Language): 
Liddle sendromu otozomal dominant geçişli, distal nefronda epi-telyal sodyum kanallarında meydana gelen mutasyon nedeniyle görülen, tuza duyarlı hipertansiyon formlarından biridir. Vakamız literatürde tanımlanan Liddle sendromlu en yaşlı hastadır ve eşlik eden hipo-kalsemisi de mevcuttur. Seksen beş yaşında, hipertansiyon öyküsü olan kadın hasta uykuya eğilim, hipokalemi ve hipokalsemi etiyolojisi araştırılmak üzere hastaneye yatırıldı. Yapılan tetkikler sonrasında vakada hiperkaliüri, plazma renin ve aldosteron düzeyinde hafif düşme gözlemlendi. Liddle sendromu tanısı konulan hasta triamterene başarılı bir şekilde tedavi edildi. Sonuç olarak metabolik alkaloz, hipokalemi, hipertansiyon ve hiperkaliürinin bir arada bulunduğu vakalarda ayırıcı tanıda Liddle sendromu akılda bulundurulmalıdır.
FULL TEXT (PDF): 
PDF icon pdf_tndt_648.pdf
  • 2
103-105
  • Turkish

REFERENCES

References: 

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