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ADRENOMEDULLİN: YENİ BİR RENAL DÜZENLEYİCİ PEPTİD

ADRENOMEDULLIN A NEW RENAL REGULATINPEPTIDE

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2002

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Adrenomedullin (ADM), a novel peptide recently isolatedfrompheochromocytoma, elicitingvasorelaxing activity, is the strongest among all known peptides. ADM mRNA has been detected in the adrenal medulla, cardiac tissue, lung, and kidney. İmmunohistochemical studies have demonstrated the localization of ADM in glomeruli, tubules, and collecting cells of the kidney. ADM has diuretic and natriuretic actions, which are mediated by increases in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. Clinically, plasma ADM and urinary levels are altered in patients with different renal disease. Further investigations are required to address the importance of ADM under various conditions.
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Abstract (Original Language): 
Yakın zamanlarda feokromositomadan izole edilen adrenomedullin (ADM) bilinenpeptidler arasında en güçlü damar genişletici etkinliğe sahiptir. ADM mRNA 'sı adrenal medulla, kalp, akciğerler ve böbreklerde saptanmıştır. İmmunhistokimyasal çalışmalarda ADM böbreğin glomerüllerinde, tübüllerinde ve toplayıcı sistemde gösterilmiştir. Diüretik ve natriüretik etkileri olan bupeptid, etkileriniglomerüler filtrasyonu artırıp, tubuler sodyum geri emilimini azaltarak yapmaktadır. Klinik çalışmalarda, plazma ve idrar ADM düzeylerinin farklı böbrek hastalıklarında değiştiği gösterilmiştir. Dolayısıyla ADM'nin çeşitli klinik durumlardaki önemini ortaya koyacak araştırmalara gereksinim vardır.
FULL TEXT (PDF): 
PDF icon pdf_tndt_404.pdf
  • 4
198-201
  • Turkish

REFERENCES

References: 

1. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifiınctional regulatory peptide. Endocr Rev 2000; 21:138-67.
2. Jougasaki M, Burnett Jr JC. Adrenomedullin as a regulator peptide. Nephrol Dial Transplant 2000; 15: 293-95.
3. Cameron VA, Fleming AM. Novel sites of adrenomedullin
gene expression in mouse and rat tissues. Endocrinology 1998; 53: 979-85.
4. Eguchi S, Hirata Y, Iwasaki H, et al. Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology 1994; 135: 2454-57.
5. Nishikimi T, Horio T, Kohmoto Y, et al: Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure. J Hypertens 2001; 19:765-73.
6. Isumi Y, Shoji H, Sugo S, et al. Regulation of adrenomedullin production in rat endothelial cells. Endocrinology 1998; 139: 838-46.
7. Hata T, Miyazaki K. Adrenomedullin in pre-eclampsia.
Lancet 1998; 351: 676-77.
8. Elsasser TH, Kahl S, Martinez A, Montuenga L, Pio R: Adrenomedullin binding protein in the plasma of multiple species: characterization by radioligand blotting. Endocrinology 1999; 140: 4908-11.
9. Hirata Y, Hayakawa H, Suzuki Y, et al. Mechanisms of adrenomedullin-induced vasodilatation in the rat kidney. Hypertension 1995; 25: 790-95.
10. McGregor D, Trougton RW, Frampton C, et al. Hypotensive and natriuretic actions of adrenomedullin in subjects with chronic renal impairment. Hypertension 2001; 37:1279-84.
11. Chini E, Chini CCS, Bolliger C, et al. Cytoprotective effects of adrenomedullin in glomeruler cell injury: Central role of
cAMP signaling pathway. Kidney Int 1997; 52: 917-25.
12. Kohno M, Yanusari K, Yokosawa K, et al. Interaction of adrenomedullin and platelet-derived growth factor on rat mesangial cell production of endothelin. Hypertension 2000; 27: 663-67.
13. Kita.T, Kitamura K; Kuwasako K, et al: Short-term modulation of the renin-angjotensin system does not alter plasma adrenomedullin concentrations in humans. J Hypertens 1998; 16: 2057-62.
14. Kinoshito H, Fujimoto S, Kitamura K, et al: Increased plasma levels of mature adrenomedullin in chronic glomerulonephritis. Nephron 2000; 86: 333-38.
15. Nitta K, Kikawada E, Uchida K,et al. Plasma levels of the mature form of the adrenomedullin and disease activity in patients with IgA nephropathy. Nephron 2000; 86: 520-21.
16. Kubo A, Iwano M, Minamino N,et al. Measurement of plasma and urinary adrenomedullin in patients with IgA nephropathy. Nephron 1998; 78: 389-94.
17. Kubo A, Nishitani Y, Minamino N,et al. Adrenomedullin gene transcription is decreased in peripheral blood mononuclear cells of patients with IgA nephropathy.
Nephron 2000; 85: 201-6.
18. Kubo A, Kurioka H, Minamino N, et al. Plasma and urinary adrenomedullin in chronic glomerulonephritis patients with
proteinuria. Nephron 1998; 80: 227-30.
19. Balat A, Çekmen M, Yürekli M, et al. Adrenomedullin and nitrite levels in children with minimal change nephrotic
syndrome. Pediatr Nephrol 2000; 15:70-73.
20. Malamaci F, Zoccali C, Parlongo S, et al. Plasma adrenomedullin during acute changes in intravascular volume in hemodialysis patients. Kidney Int 1998; 54: 1697-1703.
21. Nishio K, Akayi Y, Murao Y, et al: Increased plasma concentrations of adrenomedullin correlate with relaxation of vascular tone in patients with septic shock. Crit Care
Med 1997; 25: 953-57.
22. Toepfer M, Lang SM, Harman G,et al. Plasma adrenomedullin levels body fluid status, and end-stage
renal failure. Nephron 1998; 80: 232-33.
23. Balat A, Çekmen M, Yürekli M, et al. Adrenomedullin and nitrite levels in children with Bartter syndrome. Pediatr
Nephrol 2000; 15: 266-70.
24. Nishitani Y, Kubo A, Iwano M, et al. Imbalance between interleukin-6 and adrenomedullin mRNA levels in peripheral blood mononuclear cells of patients with lupus nephritis. Clin Exp Immunol 2001; 124: 330-36.
25. Dotsch J, Hanze J, Knufer V, et al. Increased urinary adrenomedullin excretion in children with urinary-tract infection. Nephrol Dial Transpl 1998; 13: 1686-89.

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