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Uzun Dönem Aşırı Sigara Kullanımının Kronik Periodontitisli Bireylerde Dişeti Oluğu Sıvısı İnterlökin 4 Düzeylerine Etkisi

The Effect of Long–Term Heavy Smoking on Gingival Crevicular Fluid IL–4 levels in Chronic Periodontitis

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Abstract (2. Language): 
Aim: The aim of this study was to evaluate the influence of long–term and heavy smoking on the gingival crevicular fluid (GCF) interleukin–4 (IL–4) levels in chronic periodontitis patients. Methods: The study population included 126 non– smoker (NS) and long–term and heavy smoker (S) chronic periodontitis patients and 17 non–smoker healthy controls. The NS and S groups were divided into three subgroups according to the probing depth (PD) categories: a: PD ≤ 3 mm, b: PD= 4–5 mm, c: PD > 5 mm. For each individual, clinical data were recorded. Results: All of the NS subgroups had higher IL–4 concentrations than the control group (p<0.05). However in the S a– and b–subgroups, IL–4 levels were found lower than that in the control group (p<0.05). The NS a– and b–subgroups showed significant negative correlations between IL–4 and gingival inflammation symptoms (p<0.05). Conclusion: Our study has supported that long–term and heavy smoking impairs the local immune response in periodontitis patients.
Abstract (Original Language): 
Amaç: Bu çalışmanın amacı; uzun dönem aşırı sigara kullanımının kronik periodontitis hastalarında dişeti oluğu sıvısı (DOS) interlökin (IL)–4 düzeylerine etkisini belirlemekti. Yöntem ve Gereç: Çalışma popülasyonu; sigara içmeyen (S–), uzun dönem aşırı sigara içen (S+) 126 kronik periodontitisli ve 17 sağlıklı bireyden (kontrol grubu) oluştu. Sigara içen ve içmeyen gruplar cep derinliği (CD) kategorilerine göre üçer alt gruba (a: CD ≤ 3 mm, b: CD= 4–5 mm, c: CD > 5 mm) ayrıldı. Bireylerden klinik ölçümler kaydedildi. Bulgular: Sigara içmeyen tüm S– alt gruplarında kontrol grubuna göre DOS IL–4 düzeyleri yüksekti (p<0.05). Ancak DOS IL–4 düzeyleri S+a ve S+b alt gruplarında K grubuna göre anlamlı derecede düşük bulundu (p<0.05). Dişeti inflamasyon belirteçleri ve IL–4 düzeyleri arasındaki korelasyonlar S–a ve S–b alt gruplarında istatistiksel olarak anlamlı ve negatifti (p<0.05). Sonuçlar: Çalışmamızın sonuçları uzun dönemli aşırı sigara kullanımının periodontitisli bireylerde lokal immün cevapta bazı bozulmalara yol açabileceğini desteklemektedir.
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