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Isparta Süleyman Demirel Üniversitesi Tıp Fakültesi bünyesinde kemoterapi tedavisi gören lösemi vakalarında G-Bantlama metodu ile sitogenetik analizler

Journal Name:

  • Süleyman Demirel Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Aim: This study aimed to determine the possible chromosomal abnormalities in leukemia patients who were diagnosed and treated in Hematology Clinics of Internal Medicine Department and Pediatric Hematology Clinic of Pediatry Deparment in Süleyman Demirel University Research Hospital.Material and Method: In study 29 patients of whom 12 in post-chemotherapeutic period, 17 in remission periods with any stage of treatment in leukemia group and 30 age-and gender-matched control person were evaluated cytogenetically. Results: Of the leukemia group; 15 had acute lymphoblastic leukemia, 5 had chronic lymphoblastic leukemia, 5 had chronic myeloid leukemia and 4 had acute myeloid leukemia. Four out of 15 patients with acute lymphoblastic leukemia, 1 of 5 with chronic lymphoblastic leukemia and 1 of 5 with chronic myeloid leukemia had different cytogenetic aberrations. t(9;22)(q34;q11) was detected in two patients, one with chronic myeloid leukemia and the other with chronic lymphoblastic leukemia.; del(17q), inv(9), inv(1), and t(12;15) are found in four ALL cases respectively. Conventional cytogenetic analysis of peripheral blood is fundamental for advanced genetic study.
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Abstract (Original Language): 
Amaç: Çalışmada Süleyman Demirel Üniversitesi Araştırma Uygulama Hastanesi Dahiliye Anabilim Dalı Hematoloji Kliniği ve Pediatri Anabilim Dalı Çocuk Hematolojisi Kliniğinde tedavisi ve takibi yapılan lösemi tanısı almış vakalarda olabilecek muhtemel kromozom anomalilerinin gözlenmesi amaçlandı. Gereç ve Yöntem: Çalışmada 12 post-kemoterapik, 17 remisyonu sağlanmış ve tedavisinin herhangi bir basamağında olan 29 lösemi vakası ile yaş ve cinsiyet olarak uyumlu 30 kontrol birey sitogenetik olarak değerlendirildi. Bulgular: Lösemi grubununu 15’i akut lenfoblastik lösemi, 5’i kronik lenfoblastik lösemi, 5’i kronik myeloid lösemi ve 4’ü akut myeloid lösemi idi. 15 akut lenfoblastik lösemi vakasının 4’ünde, 5 kronik lenfositik lösemi ve kronik myeloid lösemi vakalarının birer tanesinde anomali tespit edilmiştir. Kronik myeloid lösemi vakalarının birinde t(9;22)(q34;q11), 4 akut lenfoblastik lösemi vakasında sırasıyla; del(17q), inv(9), inv(1) ve t(12;15), kronik lenfositik lösemi vakalarından birinde ise t(9;22)(q34;q11) tespit edilmiştir. Periferik kandan konvansiyonel sitogenetik analizler daha ileri genetik tetkiklere temel oluşturmaktadır.
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