You are here

Bilateral overektomi ve unilateral nefrektominin diğer böbrek dokusu üzerine olan etkileri

Effects of bilateral overektomy and unilateral nephrectomy on other renal tissue

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
The renin angiotensin system is thought to be modulated by gonadal steroids. After unilateral nephrectomy and unilateral nephrectomy + bilateral ovariectomy, occured changes were investigated in this study. Right nephrec-tomized and rigth nephrectomized + bilateral ovariectomized femaie rats ieft kidneys were examined histopatho-logically after four week. Severe inflammatory reaction was observed in only nephrectomized rats after four week. Moreover acut renal ischaemia was observed in the unilateral nephrectomized + total ovariectomized rats İeft kid-ney. Our results showed that gonadal steroids may have a role in modulating acut renal ischaemia.
Abstract (Original Language): 
Renin antiotensin sisteminin gonada! steroidlerle düzenlendiği düşünülmektedir. Bu çalışmada unilateral nefrekto-mi ve uniiatreal nefrektomi + bilateral ovarektomi sonrasında diğer böbrek dokusunda meydana gelen histopa-tolojik değişiklikler araştırıldı. Dişi sıçanlara sağ nefrektomi ve bilateral overektomi uygulandı. Sol böbrekler ise bir ay sonra histolojik incelemelerde bulunmak üzere alındı. Sadece nefrektomi uygulaması, böbrek dokusunda, şiddetli inflamatuvar reaksiyon geliştirdi. Overektomi + unilateral nefrektomi, akut renal iskemiye neden oldu. Iskemi sonucu böbrek dokusunda hasar gelişti. Sonuçlarımız gonadal steroidlerin, akut renal iskemiyi düzenleyen bir role sahip olduğunu gösterdi.
83-88

REFERENCES

References: 

1. Novick AC and Streem SB. Campbell's Urology. Vol III. W.B. Saunders Company, Philadelphia 1992, pp 2413¬89.
2. Semerciöz A, Kelestimur H, Üstündağ B, Abdulkerim K. Baltacı, Yekeler H, Sarsılmaz M, et. al. Plasma renin activity and kidney damage in response to acute renal ischaemia and ramipril treatment in ovariectomised and uninephrectomised rats. Med Sci Res 1997; 25: 533-6.
3. Osbome-Pellegrin MJ, Coutard M. Effectof contralater-al nephrectomy alone or in association rat renal artery lesions. Atherosclerosis 1985; 57 (2-3) : 267-80.
4. Shakhlamov VA, Shutka BV. Ultrastructural changes in the microcirculatory bed and filtration barrier of the kid¬ney during temporary ischemia after uniiaterally neph-tectomy. Arkh Anat Gistol Embriol 1986; 91 (10): 76-81.

5. Soukupova M, Hnevkovsky P. Najbrt J. Effect of age on kidney hyperplasia in the rat after unilateral nephrecto-my. Adv Exp Med Biol 1975: 53 : 297-305.
6. Zufarov KA. Gontmakher VM, Sagdullaev ZZ. Compensatory renal hypertrophy after nephrectomy. Ontogenez 1975; 6 (4) : 363-7.
7. Gobe GC. Axelsen RA, Searle JW. Cellular events in expt=rimenîal unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy. Lab Invest 1990: 63 (6) : 770-9.
8. Andrews PM. The presence of proximal tubulfilike OBÜS in the kidney parietal epithelia response to unilateral nephrectomy. Anat Rec 1981: 200 (1) : 61-5.
9. Kretzler M, Koeppen-Hagemann I, Kriz W. Podocyt damage is a critical step İn the development of glomerulasclerosis in the unînephrectomised-desoxy-corticosterone hypertensive rat. Virchow Arch 1994; 425 (2) : 181-93.

10. Togashi K. Rapid restoration of injured kidney after immediate removal of opposite normal kidney. İn com-parison with deleyed contralateral nephrectomy. Açta Pathol Jpn 1982: 32 (5) : 749-57.
11. Khrushchov Ng. Lange MA, Satdykova GP. Electron microscopic and autoradiographic study of giant cells of foreign bodies in the focus of aseptic inflammation. Arkh Anat Gistol Embriol 1978; 75 (8) : 43-9.
12. Olivetti G. Anversa P. Rigamonti W. Vitali Mazza L. Loud AV. Morphometry of the renal corpuscule during normal postnatal growth and compensatory hypertro-phy. A light microscope study. J. Cel Biol 1977; 75: 573-85.
13. Romen W. On the pathogenesis of the glomeruloscle-rosis ultrasîructural and autoradiographic investigafions on the rat kidney. Veroff Pathol 1976: 102 : 1-101.
14. Pfalber W, Seppi T, Ohno A, Giebisch G, Beck FX. Ouantitative morphology of renal cortical structures during compensatory hypertrophy. Exp Nephrol 1998: 6 (4) : 308-319.

Thank you for copying data from http://www.arastirmax.com