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Kronik Böbrek Yetmezlikli Hastalarda Gabapentin Toksisitesi; Olgu Serimiz

Gabapentin Toxicity in Patients with Chronic Kidney Disease; Series of Our Cases

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2013
DOI: 
10.5262/tndt.2013.1003.10

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
Gabapentin is an anticonvulsant with analgesic and anxiolytic effects and also an agent used for treatment of a variety of chronic neuropathic pains. Because gabapentin is eliminated solely through the kidney, kidney failure poses a risk for gabapentin accumulation and toxicity. Gabapentin toxicity in kidney failure hasn’t been clearly proved till now. We want to emphasize the gabapentin toxicity on fi ve cases with chronic kidney diasease at the present study.
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Abstract (Original Language): 
Gabapentin, kronik nöropatik ağrı tedavisinde kullanılan analjezik ve anksiyolitik etkili bir antikonvülzandır. Gabapentin yalnızca böbrekten atıldığı için, böbrek yetmezliği gabapentin toksisitesi için bir risk faktörüdür. Böbrek yetmezliğinde gabapentin toksisitesi tam olarak gösterilmemiştir. Bu yazımızda, kronik böbrek yetmezlikli (KBY) beş hastada gelişen gabapentin toksistesini bildireceğiz.
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  • 3
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299
  • Turkish

REFERENCES

References: 

1. Sills GJ: The mechanisms of action of gabapentin and pregabalin.
Curr Opin Pharmacol 2006; 6(1): 108-113
2. Blum RA, Comstock TJ, Sica DA, Schultz RW, Keller E, Reetze P,
Bockbrader H, Tuerck D, Busch JA, Reece PA: Pharmacokinetics of
gabapentin in subjects with various degrees of renal function. Clin
Pharmacol Ther 1994; 56(2): 154-159
3. Zand L, McKian KP, Qian Q: Gabapentin toxicity in patients with
chronic kidney disease: A preventable cause of morbidity. Am J
Med 2010; 123(4): 367-373
4. Mansfi eld AS, Qian Q: 71-year-old man with chronic kidney failure
and sudden change of mental status. Mayo Clin Proc 2009; 84(11):
5-8
5. Dogukan A, Aygen B, Berilgen MS, Dag S, Bektas S, Gunal AI:
Gabapentin-induced coma in a patient with renal failure. Hemodial
Int 2006; 10(2): 168-169
6. Wong MO, Eldon MA, Keane WF, Türck D, Bockbrader HN,
Underwood BA, Sedman AJ, Halstenson CE: Disposition of
gabapentin in anuric subjects on hemodialysis. J Clin Pharmacol
1995; 35(6): 622-626
7. Miller A, Price G: Gabapentin toxicity in renal failure: The
importance of dose adjustment. Pain Med 2009; 10(1): 190-192
8. Bookwalter T, Gitlin M: Gabapentin-induced neurologic toxicities.
Pharmacotherapy 2005; 25(12): 1817-1819
9. Bassilios N, Launay-Vacher V, Khoury N, Rondeau E, Deray G,
Sraer JD: Gabapentin neurotoxicity in a chronic haemodialysis
patient. Nephrol Dial Transplant 2001; 16(10): 2112-2113
10. Lipson J, Lavoie S, Zimmerman D: Gabapentin-induced myopathy
in 2 patients on short daily hemodialysis. Am J Kidney Dis 2005;
45: 100-104
11. Guddati AK, Zafar Z, Cheng JT, Mohan S: Treatment of gabapentininduced
myoclonus with continuous renal replacement therapy.
Indian J Nephrol 2012; 22(1): 59-61
12. Hung TY, Seow VK, Chong CF, Wang TL, Chen CC: Gabapentin
toxicity: An important cause of altered consciousness in patients
with uraemia. Emerg Med J 2008; 25(3): 178-179

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