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Üremik Hastalarda Grelin Düzeyleri ile Mide Mukozasında Helicobacter Pylori Varlığı Arasındaki İlişki

The Relationship Between Ghrelin Levels and the Presence of Helicobacter Pylori in the Gastric Mucosa in Uremic Patients

Journal Name:

Publication Year:

DOI: 
10.5262/tndt.2013.1003.06

Keywords (Original Language):

Abstract (2. Language): 
OBJECTIVE: Helicobacter pylori (H. pylori) infection is an important risk factor for chronic gastritis and peptic ulcer. Ghrelin is mostly secreted by gastric mucosa. The aim of the study is to examine the relationship between H. Pylori and ghrelin levels in uremic patients. MATERIAL and METHODS: A total of 91 patients [control group (CG, n=29), hemodialysis group (HD, no=21), peritoneal dialysis group(PD, no=12), predialysis group(PreG, n=29)] were involved. Patients using drugs active on H. pylori and/or gastric acidity were excluded. Besides demographic and biochemical parameters, patients were examined endoscopically; and H. Pylori was searched histopathologically. RESULTS: H. pylori was found to be positive in 62 patients (68.1%). Those patients were not different from H. pylori negative group regarding demographic and biochemical parameters. H. pylori positivity was statistically similar in patient groups. Ghrelin levels of uremic groups (HD, PD and PreG) were signifi cantly higher than that of CG (4.22±1.00ng/ml vs. 2.81±0.37ng/ml, p<0.001). Ghrelin level was higher in the predialysis group compared with the HD group (4.49±1.18ng/ml vs. 3.81±0.98ng/ml, p=0.040). Ghrelin levels of H. pylori positive and negative patients were not different (3.83±1.2ng/ml vs. 3.65±1.0ng/ml, p=0.50). CONCLUSION: Ghrelin levels are elevated in uremia, but there is no relationship between ghrelin level and H. pylori positivity in uremic patients.
Abstract (Original Language): 
AMAÇ: Helicobacter pylori (H. pylori) enfeksiyonu kronik gastrit ve peptik ülser için önemli bir risk faktörüdür. Grelin en çok mide mukozasından salınır. Çalışmanın amacı, üremik hastalarda H. Pylori ile grelin düzeyleri arasındaki ilişkiyi incelemektir. GEREÇ ve YÖNTEMLER: Toplam 91 hasta [kontrol grubu (CG, n=29), hemodiyaliz grubu (HD, no=21), periton diyalizi grubu (PD, no=12), prediyaliz grubu (PreG, n=29)] dahil edildi. H. pylori ve/ veya gastrik asidite üzerine etkili ilaç kullanan hastalar dışlandı. Demografi k ve biyokimyasal veriler yanında, hastalar endoskopik olarak muayene edildiler ve H. pylori varlığı histopatolojik olarak arandı. BULGULAR: H. pylori 62 hastada (%68.1) pozitif saptandı. Bu hastalar demografi k ve biyokimyasal parametreler açısından H. pylori negatif gruptan farklı değildiler. H. pylori pozitifl iği hasta gruplarında istatistiksel olarak benzerdi. Grelin düzeyleri üremik gruplarda (HD, PD ve PreG) kontrol grubundan anlamlı derecede yüksekti (4,22±1,00ng/ml ve 2,80±0,37ng/ml, p<0,001). Grelin düzeyleri prediyaliz grupta HD grubuna kıyasla daha yüksek bulundu (4,49±1,18 ng/ml ve 3,81±0,98 ng/ml, p=0,040). Grelin düzeyleri H. pylori pozitif ve negatif hastalarda farklı değildi (3,83±1,2 ng/ml ve 3,65±1,0ng/ ml, p=0,50). SONUÇ: Grelin düzeyleri üremide yüksektir, fakat grelin düzeyleri ile H. pylori pozitifl iği arasında ilişki yoktur.
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REFERENCES

References: 

1. Andriulli A, Malfi B, Recchia S, Ponti V, Triolo G, Segoloni G:
Patients with chronic renal failure are not at a risk of developing
chronic peptic ulcers. Clin Nephrol 1985; 23(5): 245-248
2. Franzin G, Musola R, Mencarelli R: Morphological changes of
the gastroduodenal mucosa in regular dialysis uraemic patients.
Histopathology 1982; 6(4): 429-4373. Khetmat H, Ahmadzad-Asl M, Amini M, Lessan-Pezeshki M,
Einollahi B, Pourfarziani V, Naseri MH, Davoudi F: Gastroduodenal
lesions and Helicobacter pylori infection in uremic
patients and renal transplant recipients. Transplant Proc 2007;
39(4): 1003-1007
4. Nardone G, Rocco A, Fiorillo M, Del Pezzo M, Autiero G, Cuomo R,
Sarnelli G, Lambiase A, Budillon G, Cianciaruso B: Gastroduodenal
lesions and Helicobacter pylori infection in dyspeptic patients with
and without chronic renal failure. Helicobacter 2005; 10(1): 53-58
5. Misra V, Misra SP, Shukla SK, Jaiswal PK, Agarwal R, Tondon S:
Endoscopic and histological changes in upper gastrointestinal tract
of patients with chronic renal failure. Indian J Pathol Microbiol
2004; 47(2): 170-173
6. Tseng GY, Lin HJ, Fang CT, Yang HB, Tseng GC, Wang PC, Hung
TL, Deng YC, Cheng YT, Huang CH: Recurrence of peptic ulcer
in uraemic and non-uraemic patients after Helicobacter pylori
eradication: A 2-year study. Aliment Pharmacol Ther 2007; 26(6):
925-933
7. Aydın S, Özkan Y, Caylak E, Aydın S: Ghrelin and its biochemical
functions: Review. Turkiye Klinikleri J Med Sci 2006; 26(3): 272-
283
8. Hosoda H, Kojima M, Kangawa K: Biological, physiological, and
pharmacological aspects of ghrelin. J Pharmacol Sci 2006; 100(5):
398-410
9. Yoshimoto A, Mori K, Sugawara A, Mukoyama M, Yahata K,
Suganami T, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao
K: Plasma ghrelin and desacyl ghrelin concentrations in renal
failure. J Am Soc Nephrol 2002; 13(11): 2748-2752
10. Pérez-Fontán M, Cordido F, Rodríguez-Carmona A, Peteiro J,
García-Naveiro R, García-Buela J: Plasma ghrelin levels in patients
undergoing haemodialysis and peritoneal dialysis. Nephrol Dial
Transplant 2004; 19(8): 2095-2100
11. Nwokolo CU, Freshwater DA, O’Hare P, Randeva HS: Plasma
ghrelin following cure of Helicobacter pylori. Gut 2003; 52(5): 637-
640
12. Tatsuguchi A, Miyake K, Gudis K, Futagami S, Tsukui T, Wada K,
Kishida T, Fukuda Y, Sugisaki Y, Sakamoto C:Effect of Helicobacter
pylori infection on ghrelin expression in human gastric mucosa. Am
J Gastroenterol 2004; 99(11): 2121-2127
13. Shiotani A, Miyanishi T, Uedo N, Iishi H: Helicobacter pylori
infection is associated with reduced circulating ghrelin levels
independent of body mass index. Helicobacter 2005; 10(5): 373–
378
14. Osawa H, Nakazato M, Date Y, Kita H, Ohnishi H, Ueno H, Shiiya
T, Satoh K, Ishino Y, Sugano K: Impaired production of gastric
ghrelin in chronic gastritis associated with Helicobacter pylori. J
Clin Endocrinol Metab 2005; 90(1): 10-16
15. Gokcel A, Gumurdulu Y, Kayaselcuk F, Serin E, Ozer B, Ozsahin
AK, Guvener N: Helicobacter pylori has no effect on plasma ghrelin
levels. Eur J Endocrinol 2003; 148(4): 423-426
16. De Korwin JD: Advantages and limitations of diagnostic methods
for H. Pylori infection. Gastroenterol Clin Biol 2003; 27: 380-39017. Aksoy DY, Aybar M, Ozaslan E, Kav T, Engin D, Ercis S, Altinok
G, Hascelik G, Uzunalimoglu B, Arslan S: Evaluation of the
Helicobacter pylori stool antigen test (HpSA) for the detection of
Helicobacter pylori infection and comparison with other methods.
Hepatogastroenterology 2003; 50(52): 1047-1049
18. Osawa H, Kita H, Ohnishi H, Nakazato M, Date Y, Bowlus CL, Ishino
Y, Watanabe E, Shiiya T, Ueno H, Hoshino H, Satoh K, Sugano K:
Changes in plasma ghrelin levels, gastric ghrelin production, and
body weight after Helicobacter pylori cure. J Gastroenterol 2006;
41(10): 954-961
19. Jun DW, Lee OY, Lee YY, Choi HS, Kim TH, Yoon BC: Correlation
between gastrointestinal symptoms and gastric leptin and ghrelin
expression in patients with gastritis. Dig Dis Sci 2007; 52(10):
2866-2872
20. Pacifi co L, Anania C, Osborn JF, Ferrara E, Schiavo E, Bonamico M,
Chiesa C: Long-term effects of Helicobacter pylori eradication on
circulating ghrelin and leptin concentrations and body composition
in prepubertal children. Eur J Endocrinol 2008; 158(3): 323-332
21. Osawa H: Ghrelin and Helicobacter pylori infection. World J
Gastroenterol 2008; 14(41): 6327-6333
22. Locatelli V, Bresciani E, Bulgarelli I, Rapetti D, Torsello A, Rindi
G, Sibilia V, Netti C: Ghrelin in gastroenteric pathophysiology. J
Endocrinol Invest 2005; 28(9): 843-848
23. Konturek PC, Brzozowski T, Walter B, Burnat G, Hess T, Hahn EG,
Konturek SJ: Ghrelin-induced gastroprotection against ischemiareperfusion
injury involves an activation of sensory afferent nerves
and hyperemia mediated by nitric oxide. Eur J Pharmacol 2006;
536(1-2): 171-181
24. Langer FB, Reza Hoda MA, Bohdjalian A, Felberbauer FX, Zacherl
J, Wenzl E, Schindler K, Luger A, Ludvik B, Prager G: Sleeve
gastrectomy and gastric banding: Effects on plasma ghrelin levels.
Obes Surg 2005; 15(7): 1024-1029
25. Isomoto H, Ueno H, Nishi Y, Yasutake T, Tanaka K, Kawano N,
Ohnita K, Mizuta Y, Inoue K, Nakazato M, Kohno S: Circulating
ghrelin levels in patients with various upper gastrointestinal
diseases. Dig Dis Sci 2005; 50(5): 833-838
26. Moss SF, Calam J, Agarwal B, Wang S, Holt PR: Induction of
gastric epithelial apoptosis by Helicobacter pylori. Gut 1996; 38(4):
498-501
27. Aydemir S, Ozdemir BH, Gur G, Dogan I, Yilmaz U, Boyacioglu
S: Effects of Helicobacter pylori infection on gastric epithelial cell
kinetics in patients with chronic renal failure. World J Gastroenterol
2005; 11(45): 7183-7187
28. Cheville NF: Uremic gastropathy in the dog. Vet Pathol 1979; 16(3):
292-309
29. Kang JY, Wu AY, Sutherland IH, Vathsala A: Prevalence of peptic
ulcer in patients undergoing maintenance hemodialysis. Dig Dis Sci
1988; 33(7): 774-778

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